The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Persistent Sodium Current in Mammalian Central Neurons
Abstract
Neurons from the mammalian CNS have a noninactivating component of the tetrodotoxin-sensitive sodium current (INaP). Although its magnitude is < 1% of the transient sodium current, INaP has functional significance because it is activated about 10 mV negative to the transient sodium current, where few voltage-gated channels are activated and neuron input resistance is high. INaP adds to synaptic current, and evidence indicates that it is present in dendrites where relatively small depolarizations will activate INaP, thereby increasing effectiveness of distal depolarizing synaptic activity. The mechanism for INaP is not known. Research in striated muscle and neurons suggests a modal change in gating of conventional sodium channels, but it is also possible that INaP flows through a distinct subtype of noninactivating sodium channels. Modulation of INaP could have a significant effect on the transduction of synaptic currents by neurons.
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Cellular and molecular biology of voltage-gated sodium channels
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Self-citationA voltage-dependent persistent sodium current in mammalian hippocampal neurons.
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Cited by
The action potential in mammalian central neurons
Bean, B. P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2148 · Cited by 1,785
Natural waking and sleep states: a view from inside neocortical neurons
Steriade, M., Timofeev, I., & Grenier, F. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.5.1969 · Cited by 1,296
Neve, K. A., Seamans, J. K., & Trantham‐Davidson, H. (2004) · Journal of Receptors and Signal Transduction · doi:10.1081/lrst-200029981 · Cited by 837
Origin of Slow Cortical Oscillations in Deafferented Cortical Slabs
Timofeev, I. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.12.1185 · Cited by 710
Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons
Raman, I. M., & Bean, B. P. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04517.1997 · Cited by 568
Metadata
- Authors
- Crill, W. E.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 1996-10
- Volume
- 58
- Issue
- 1
- Pages
- 349-362
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2148901385
- Cited by
- 632
- References
- 39
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
