The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor
Abstract
A calcitonin receptor complementary DNA (cDNA) was cloned by expression of a cDNA library from a porcine kidney epithelial cell line in COS cells. The 482-amino acid receptor has high affinity for salmon calcitonin (dissociation constant K d ≈ 6 nM) and is functionally coupled to increases in intracellular cyclic adenosine monophosphate (cAMP). The receptor shows no sequence similarity to other reported G protein-coupled receptors but is homologous to the parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor, indicating that the receptors for these hormones, which regulate calcium homeostasis, represent a new family of G protein-coupled receptors.
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Cites
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Cited by
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
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The cloning of a family of genes that encode the melanocortin receptors
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Metadata
- Authors
- Lin, H. Y., Harris, T. L., Flannery, M. S., Aruffo, A., Kaji, E. H., Gorn, A., Kolakowski, L. F., Lodish, H. F., & Goldring, S. R.
- Venue
- Science
- Published
- 1991-11-15
- Volume
- 254
- Issue
- 5034
- Pages
- 1022-1024
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966819735
- Cited by
- 451
- References
- 16
- FWCI
- 12.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor. https://app.cochat.ai/papers/10.1126/science.1658940
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- Lin, H. Y., Harris, T. L., Flannery, M. S., Aruffo, A., Kaji, E. H., Gorn, A., Kolakowski, L. F., Lodish, H. F., & Goldring, S. R. (1991). Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor. Science. https://doi.org/10.1126/science.1658940
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
