Cited by 2,182Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

G 1 Events and Regulation of Cell Proliferation

Pardee, Arthur B.·1989·Science

Abstract

Cells prepare for S phase during the G1 phase of the cell cycle. Cell biological methods have provided knowledge of cycle kinetics and of substages of G1 that are determined by extracellular signals. Through the use of biochemical and molecular biological techniques to study effects of growth factors, oncogenes, and inhibitors, intracellular events during G1 that lead to DNA synthesis are rapidly being discovered. Many cells in vivo are in a quiescent state (G0), with unduplicated DNA. Cells can be activated to reenter the cycle during G1. Similarly, cells in culture can be shifted between G0 and G1. These switches in and out of G1 are the main determinants of post-embryonic cell proliferation rate and are defectively controlled in cancer cells.

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Crossref · 10.1126/science.2683075

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Authors
Pardee, A. B.
Affiliations
Harvard University (US)
Corresponding author
Pardee, Arthur B.
Venue
Science
Published
1989-11-03
Volume
246
Issue
4930
Pages
603-608
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1974391793
Cited by
2,182
References
136
Citations by year
2026: 5 · 2025: 13 · 2024: 10 · 2023: 13 · 2022: 14 · 2021: 18 · 2020: 29 · 2019: 20 · 2018: 28 · 2017: 17 · 2016: 17 · 2015: 27 · 2014: 23 · 2013: 32 · 2012: 29
FWCI
18.06
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
U.S. Public Health Service (24571)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
G1 phase, cell cycle regulation, cell proliferation, G0 to G1 transition, quiescence, growth factors, oncogenes, cell cycle inhibitors, S phase, DNA synthesis, cancer cells, cell cycle kinetics
MeSH terms
Animals, Cell Cycle, Cell Division, Cell Membrane, Cell Nucleus, Humans, Interphase, Models, Biological, Neoplasms, Signal Transduction, Gene Expression

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