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Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice
Abstract
Neonatal thymectomy of mice, when no ectopic thymus existed, constantly resulted in developmental arrest of the ovary but not of the testis; it also caused sterility in the female. The ovaries of thymectomized mice were extremely small and were characterized by absence of follicles and corpora lutea. Such an ovarian dysgenesia was observed when the mice were thymectomized at 3 days of age, but not at 7 days or later; it was prevented by thymus grafting.
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Citations
Cited by
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THE NOD MOUSE: A Model of Immune Dysregulation
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Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension
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Metadata
- Authors
- Nishizuka, Y., & Sakakura, T.
- Venue
- Science
- Published
- 1969-11-07
- Volume
- 166
- Issue
- 3906
- Pages
- 753-755
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070213858
- Cited by
- 591
- References
- 0
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice. https://app.cochat.ai/papers/10.1126/science.166.3906.753
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- Nishizuka, Y., & Sakakura, T. (1969). Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice. Science. https://doi.org/10.1126/science.166.3906.753
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
