T cell anergy

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

Groux, H., O’Garra, A., Bigler, M., Rouleau, M., Antonenko, S. V., de Vries, J. E., & Roncarolo, M. G. (1997) · Nature · doi:10.1038/39614 · Cited by 3,588 · see citing works

CD4+CD25+ suppressor T cells: more questions than answers

Shevach, E. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri821 · Cited by 2,097 · see citing works

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

Zajac, A. J., Blattman, J. N., Murali-Krishna, K., Sourdive, D. J. D., Suresh, M., Altman, J. D., & Ahmed, R. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.12.2205 · Cited by 1,978 · see citing works

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

Kisielow, P., Blüthmann, H., Staerz, U., Steinmetz, M., & von Boehmer, H. (1988) · Nature · doi:10.1038/333742a0 · Cited by 1,793 · see citing works

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

Jordan, M. S., Boesteanu, A. C., Reed, A. J., Petrone, A. L., Holenbeck, A. E., Lerman, M. A., Naji, A., & Caton, A. J. (2001) · Nature Immunology · doi:10.1038/86302 · Cited by 1,661 · see citing works

Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

Sakaguchi, S., Sakaguchi, N., Shimizu, J., Yamazaki, S., Sakihama, T., Itoh, M., Kuniyasu, Y., Nomura, T., Toda, M., & Takahashi, T. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1820102.x · Cited by 1,505 · see citing works

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

Mueller, D. L., Jenkins, M. K., & Schwartz, R. H. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.002305 · Cited by 1,501 · see citing works

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.

Asano, M., Toda, M., Sakaguchi, N., & Sakaguchi, S. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.387 · Cited by 1,328 · see citing works

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

Jenkins, M. K., & Schwartz, R. H. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.165.2.302 · Cited by 1,176 · see citing works

In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

Barrat, F. J., Cua, D. J., Boonstra, A., Richards, D. F., Crain, C., Savelkoul, H. F. J., Malefyt, R. D. W., Coffman, R. L., Hawrylowicz, C. M., & O’Garra, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011629 · Cited by 1,161 · see citing works

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo.

Kearney, E. R., Pape, K., Loh, D., & Jenkins, M. (1994) · Immunity · doi:10.1016/1074-7613(94)90084-1 · Cited by 1,126 · see citing works

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

Webb, S. R., Morris, C., & Sprent, J. (1990) · Cell · doi:10.1016/0092-8674(90)90420-j · Cited by 885 · see citing works

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells

Groux, H., Bigler, M., de Vries, J. D., & Roncarolo, M. (1996) · Journal of Experimental Medicine · doi:10.1084/jem.184.1.19 · Cited by 876 · see citing works

Stimulation of p21ras upon T-cell activation

Downward, J., Graves, J. D., Warne, P. H., Rayter, S., & Cantrell, D. A. (1990) · Nature · doi:10.1038/346719a0 · Cited by 841 · see citing works

Type 1 T regulatory cells

Roncarolo, M. G., Bacchetta, R., Bordignon, C., Narula, S. K., & Levings, M. K. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1820105.x · Cited by 814 · see citing works

Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4

Chang, C.-C., Ciubotariu, R., Manavalan, J. S., Yuan, J., Colovai, A. I., Piazza, F., Lederman, S. M., Colonna, M., Cortesini, R., Dalla‐Favera, R., et al. (2002) · Nature Immunology · doi:10.1038/ni760 · Cited by 803 · see citing works

CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses

Kingsley, C. I., Karim, M., Bushell, A., & Wood, K. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1080 · Cited by 742 · see citing works

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

Perez, V. L., Parijs, L. V., Biuckians, A., Zheng, X. X., Strom, T. B., & Abbas, A. K. (1997) · Immunity · doi:10.1016/s1074-7613(00)80284-8 · Cited by 715 · see citing works

Transcriptional Mechanisms Underlying Lymphocyte Tolerance

Macián, F., Garcia-Cozar, F. J., Im, S., Horton, H. F., Byrne, M. C., & Rao, A. (2002) · Cell · doi:10.1016/s0092-8674(02)00767-5 · Cited by 687 · see citing works

Peripheral Selection of the T Cell Repertoire

Rocha, B., & von Boehmer, H. (1991) · Science · doi:10.1126/science.1900951 · Cited by 656 · see citing works

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

Rogers, P., Song, J. J., Gramaglia, I., Killeen, N. P., & Croft, M. (2001) · Immunity · doi:10.1016/s1074-7613(01)00191-1 · Cited by 645 · see citing works

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

Weiss, A., Imboden, J. B., Hardy, K. J., Manger, B., Terhorst, C., & Stobo, J. D. (1986) · Annual Review of Immunology · doi:10.1146/annurev.iy.04.040186.003113 · Cited by 621 · see citing works

Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice

Nishizuka, Y., & Sakakura, T. (1969) · Science · doi:10.1126/science.166.3906.753 · Cited by 592 · see citing works

Models of T cell anergy: is there a common molecular mechanism?

Schwartz, R. H. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.1.1 · Cited by 568 · see citing works

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells

Steinbrink, K., Jonuleit, H., Müller, G., Schuler, G., Knop, J., & Enk, A. (1999) · Blood · doi:10.1182/blood.v93.5.1634 · Cited by 509 · see citing works

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

Rammensee, H., Kroschewski, R., & Frangoulis, B. (1989) · Nature · doi:10.1038/339541a0 · Cited by 450 · see citing works

Cloning and expression of murine immune interferon cDNA.

Gray, P. W., & Goeddel, D. V. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.19.5842 · Cited by 450 · see citing works

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

Lamb, J. R., Skidmore, B. J., Green, N., et al. (1983) · The Journal of Experimental Medicine · doi:10.1084/jem.157.5.1434 · Cited by 436 · see citing works

CTLA-4 regulates induction of anergy in vivo

Greenwald, R. J., Boussiotis, V. A., Lorsbach, R. B., Abbas, A. K., & Sharpe, A. H. (2001) · Immunity · doi:10.1016/s1074-7613(01)00097-8 · Cited by 428 · see citing works

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 + T Cells

Li, W., Whaley, C. D., Mondino, A., & Mueller, D. L. (1996) · Science · doi:10.1126/science.271.5253.1272 · Cited by 427 · see citing works

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

Boussiotis, V. A., Freeman, G. J., Berezovskaya, A., Barber, D. L., & Nadler, L. M. (1997) · Science · doi:10.1126/science.278.5335.124 · Cited by 408 · see citing works

Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness.

Quill, H., & Schwartz, R. H. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.11.3704 · Cited by 388 · see citing works

Anergic T Cells as Suppressor Cells in Vitro

Lombardi, G., Sidhu, S., Batchelor, R. J., et al. (1994) · Science · doi:10.1126/science.8202711 · Cited by 372 · see citing works

Blocked Ras Activation in Anergic CD4 + T Cells

Fields, P. E., Gajewski, T. F., & Fitch, F. W. (1996) · Science · doi:10.1126/science.271.5253.1276 · Cited by 370 · see citing works

T Regulatory Cells 1 Inhibit a Th2-Specific Response In Vivo

Cottrez, F., Hurst, S. D., Coffman, R. L., & Groux, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.4848 · Cited by 366 · see citing works

Transgenic Mice and Analysis of B-Cell Tolerance

Goodnow, C. C. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.002421 · Cited by 359 · see citing works

In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

Rellahan, B. L., Jones, L. A., Kruisbeek, A. M., Fry, A. M., & Matis, L. A. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.4.1091 · Cited by 357 · see citing works

Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody.

Jenkins, M. K., Chen, C., Jung, G., Mueller, D. L., & Schwartz, R. H. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.1.16 · Cited by 355 · see citing works

Das Verhalten der kutanen Tuberkulinreaktion während der Masern

von Pirquet, C. F. (1908) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0028-1135624 · Cited by 343 · see citing works

Reversal of in vitro T cell clonal anergy by IL-2 stimulation

Beverly, B., Kang, S., Lenardo, M. J., & Schwartz, R. H. (1992) · International Immunology · doi:10.1093/intimm/4.6.661 · Cited by 333 · see citing works

A Nondeletional Mechanism of Thymic Self Tolerance

Ramsdell, F., Lantz, T., & Fowlkes, B. J. (1989) · Science · doi:10.1126/science.2511629 · Cited by 318 · see citing works

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

Kang, S., Beverly, B., Tran, A.-C., Brorson, K., Schwartz, R. H., & Lenardot, M. J. (1992) · Science · doi:10.1126/science.257.5073.1134 · Cited by 318 · see citing works

Oral Tolerance: Mechanisms and Therapeutic Applications

Faria, A. M. C., & Weiner, H. L. (1999) · Advances in immunology · doi:10.1016/s0065-2776(08)60787-7 · Cited by 311 · see citing works

Prevention of T Cell Anergy by Signaling Through the γ c Chain of the IL-2 Receptor

Boussiotis, V. A., Barber, D. L., Nakarai, T., Freeman, G. J., Gribben, J. G., Bernstein, G. M., D’Andrea, A. D., Ritz, J., & Nadler, L. M. (1994) · Science · doi:10.1126/science.7973657 · Cited by 307 · see citing works

Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice.

Kawabe, Y., & Ochi, A. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.4.1065 · Cited by 306 · see citing works

Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.

Jenkins, M. K., Pardoll, D. M., Mizuguchi, J., Chused, T. M., & Schwartz, R. H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.15.5409 · Cited by 298 · see citing works

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

Powell, J. D., Lerner, C. G., & Schwartz, R. H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.5.2775 · Cited by 290 · see citing works

Naturally anergic and suppressive CD25+CD4+ T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation

Kuniyasu, Y., Takahashi, T., Itoh, M., Shimizu, J., Toda, G., & Sakaguchi, S. (2000) · International Immunology · doi:10.1093/intimm/12.8.1145 · Cited by 289 · see citing works

Homeostatic T Cell Proliferation

Surh, C. D., & Sprent, J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.f9 · Cited by 277 · see citing works

Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

Sebzda, E., Bracke, M., Tugal, T., Hogg, N., & Cantrell, D. A. (2002) · Nature Immunology · doi:10.1038/ni765 · Cited by 275 · see citing works

Clonal anergy: Persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen

Nossal, G. J. V., & Pike, B. L. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1602 · Cited by 254 · see citing works

Profound deletion of mature T cells in vivo by chronic exposure to exogenous superantigen

McCormack, J. E., Callahan, J. E., Kappler, J. W., & Marrack, P. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.9.3785 · Cited by 234 · see citing works

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

Boussiotis, V. A., Freeman, G. J., Taylor, P. A., Berezovskaya, A., Grass, I., Blazar, B. R., & Nadler, L. M. (2000) · Nature Medicine · doi:10.1038/73144 · Cited by 231 · see citing works

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance

Bansal‐Pakala, P., Jember, A. G.-H., & Croft, M. (2001) · Nature Medicine · doi:10.1038/90942 · Cited by 231 · see citing works

Regulating the Immune Response to Transplants

Waldmann, H., & Cobbold, S. P. (2001) · Immunity · doi:10.1016/s1074-7613(01)00120-0 · Cited by 231 · see citing works

Levels of Peripheral T Cell Tolerance Induced by Different Doses of Tolerogen

Ferber, I., Schönrich, G., Schenkel, J., et al. (1994) · Science · doi:10.1126/science.8303275 · Cited by 230 · see citing works

Regulation of Lck activity by CD4 and CD28 in the immunological synapse

Holdorf, A. D., Lee, K., Burack, R., Allen, P. M., & Shaw, A. S. (2002) · Nature Immunology · doi:10.1038/ni761 · Cited by 226 · see citing works

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance.

Rocha, B., Grandien, A., & Freitas, A. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.3.993 · Cited by 217 · see citing works

Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo

Buer, J., Lanoue, A., Franzke, A., Cordier, C., von Boehmer, H., & Sarukhan, A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.2.177 · Cited by 214 · see citing works

Maintenance of in Vivo Tolerance by Persistence of Antigen

Ramsdell, F., & Fowlkes, B. J. (1992) · Science · doi:10.1126/science.257.5073.1130 · Cited by 209 · see citing works

The role of cell division in the induction of clonal anergy

Jenkins, M. K. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90137-v · Cited by 197 · see citing works

Direct Evidence That Functionally Impaired CD4+ T Cells Persist In Vivo Following Induction of Peripheral Tolerance

Pape, K. A., Merica, R. R., Mondino, A., Khoruts, A., & Jenkins, M. K. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.4719 · Cited by 192 · see citing works

T‐Cell Unresponsiveness in vivo and in vitro: Fine Specificity of Induction and Molecular Characterization of the Unresponsive State

Jenkins, M. K., Pardoll, D., Mizuguchi, J., et al. (1987) · Immunological Reviews · doi:10.1111/j.1600-065x.1987.tb00502.x · Cited by 191 · see citing works

Split Anergy in a CD8 + T Cell: Receptor-dependent Cytolysis in the Absence of Interleukin-2 Production

Otten, G. R., & Germain, R. N. (1991) · Science · doi:10.1126/science.1900952 · Cited by 189 · see citing works

Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen.

Rocha, B., Tanchot, C., & von Boehmer, H. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.5.1517 · Cited by 185 · see citing works

Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity

Hanahan, D. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80085-x · Cited by 184 · see citing works

Involvement of APO2 ligand/TRAIL in activation-induced death of Jurkat and human peripheral blood T cells

Martínez‐Lorenzo, M. J., Álava, M. A., Gamen, S., Kim, K. J., Chuntharapai, A., Piñeiro, A., Naval, J., & Anel, A. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199809)28:09 · Cited by 182 · see citing works

Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy

Wells, A. D., Walsh, M. C., Bluestone, J. A., & Turka, L. A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13220 · Cited by 172 · see citing works

Th2 cell clonal anergy as a consequence of partial activation.

Sloan‐Lancaster, J., Evavold, B. D., & Allen, P. M. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.4.1195 · Cited by 169 · see citing works

Comparison of Activation versus Induction of Unresponsiveness of Virus-Specific CD4+ and CD8+ T Cells upon Acute versus Persistent Viral Infection

Oxenius, A., Zinkernagel, R. M., & Hengartner, H. (1998) · Immunity · doi:10.1016/s1074-7613(00)80628-7 · Cited by 163 · see citing works

Anergic T Cells Inhibit the Antigen-Presenting Function of Dendritic Cells

Vendetti, S., Chai, J., Dyson, J., Simpson, E., Lombardi, G., & Lechler, R. I. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1175 · Cited by 162 · see citing works

T-cell Clonal AnergyPreprint

Schwartz, R. H., Mueller, D. L., Jenkins, M. K., & Quill, H. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.072 · Cited by 159 · see citing works

CD8+ T Cells Become Nonresponsive (Anergic) Following Activation in the Presence of Costimulation

Deeths, M. J., Kedl, R. M., & Mescher, M. F. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.1.102 · Cited by 148 · see citing works

An accessory cell-derived costimulatory signal acts independently of protein kinase C activation to allow T cell proliferation and prevent the induction of unresponsiveness.

Mueller, D. L., Jenkins, M. K., & Schwartz, R. H. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.8.2617 · Cited by 148 · see citing works

Conditions That Induce Tolerance in Mature CD4+ T Cells

Lanoue, A., Bona, C. A., von Boehmer, H., & Sarukhan, A. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.3.405 · Cited by 146 · see citing works

Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

Essery, G., Feldmann, M., & Lamb, J. R. (1988) · PubMed · Cited by 141 · see citing works

Self-antigen presentation by thymic stromal cells: a subtle division of labor

Klein, L., & Kyewski, B. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00069-2 · Cited by 134 · see citing works

The structure and expression of the murine gene encoding granulocyte‐macrophage colony stimulating factor: evidence for utilisation of alternative promoters.

Stanley, E. G., Metcalf, D., Sobieszczuk, P., et al. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03972.x · Cited by 130 · see citing works

Modifications of CD8+ T Cell Function during In Vivo Memory or Tolerance Induction

Tanchot, C., Guillaume, S., Delon, J., Bourgeois, C., Franzke, A., Sarukhan, A., Trautmann, A., & Rocha, B. (1998) · Immunity · doi:10.1016/s1074-7613(00)80563-4 · Cited by 130 · see citing works

Autoreactivity, dynamic tuning and selectivity

Grossman, Z., & Paul, W. E. (2001) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00280-1 · Cited by 129 · see citing works

Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells

Terrence, K., Pavlovich, C. P., Matechak, E. O., & Fowlkes, B. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.537 · Cited by 127 · see citing works

Adaptive Tolerance of CD4+ T Cells In Vivo: Multiple Thresholds in Response to a Constant Level of Antigen Presentation

Tanchot, C., Barber, D. L., Chiodetti, L., & Schwartz, R. H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.2030 · Cited by 124 · see citing works

The −180 Site of the IL-2 Promoter Is the Target of CREB/CREM Binding in T Cell Anergy

Powell, J. D., Lerner, C. G., Ewoldt, G. R., & Schwartz, R. H. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6631 · Cited by 124 · see citing works

Tolerance in Transgenic Mice Expressing Major Histocompatibility Molecules Extrathymically on Pancreatic Cells

Burkly, L. C., Lo, D. D., & Flavell, R. A. (1990) · Science · doi:10.1126/science.1694042 · Cited by 113 · see citing works

CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy.

Boussiotis, V. A., Freeman, G. J., Griffin, J. D., Gray, G. S., Gribben, J. G., & Nadler, L. M. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.5.1665 · Cited by 113 · see citing works

Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells

Mondino, A., Whaley, C. D., DeSilva, D. R., Li, W., Jenkins, M. K., & Mueller, D. L. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.5.2048 · Cited by 112 · see citing works

Interleukin 2 regulates immune interferon (IFN gamma) production by normal and suppressor cell cultures.

Torres, B. A., Farrar, W. L., & Johnson, H. M. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.128.5.2217 · Cited by 106 · see citing works

Th1 and Th2 clones differ in their response to a tolerogenic signal.

Gilbert, K. M., Hoàng, K. T., & Weigle, W. O. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.6.2063 · Cited by 100 · see citing works

Activation and differentiation requirements of primary T cells in vitro.

Sagerström, C. G., Kerr, E. M., Allison, J. P., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8987 · Cited by 99 · see citing works

The contributions of T‐cell anergy to peripheral T‐cell tolerance

Lechler, R. I., Chai, J., Marelli‐Berg, F. M., & Lombardi, G. (2001) · Immunology · doi:10.1046/j.1365-2567.2001.01250.x · Cited by 98 · see citing works

Anergic Th1 cells express altered levels of the protein tyrosine kinases p56lck and p59fyn

Quill, H., Riley, M. P., Cho, E. A., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.9.2887 · Cited by 88 · see citing works

Role of Egr-2 in Up-regulation of Fas Ligand in Normal T Cells and Aberrant Double-negative lpr and gld T Cells

Mittelstadt, P. R., & Ashwell, J. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.5.3222 · Cited by 86 · see citing works

CD28, IL-2-Independent Costimulatory Pathways for CD8 T Lymphocyte Activation

Sepulveda, H., Cerwenka, A., Morgan, T., & Dutton, R. W. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.3.1133 · Cited by 84 · see citing works

Activation-Induced Nonresponsiveness: A Th-Dependent Regulatory Checkpoint in the CTL Response

Tham, E. L., Shrikant, P. A., & Mescher, M. F. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1190 · Cited by 83 · see citing works

Anergy in Peripheral Memory Cd4+ T Cells Induced by Low Avidity Engagement of T Cell Receptor

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Antagonistic Roles for CTLA-4 and the Mammalian Target of Rapamycin in the Regulation of Clonal Anergy: Enhanced Cell Cycle Progression Promotes Recall Antigen Responsiveness

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