Plus and Minus Single-Stranded DNA Separately Encapsidated in Adeno-Associated Satellite Virions
Abstract
Based on physical and chemical determinations, the mnolecular weight of the type 4 adeno-satellite virus is 5.4 X 10(6) daltons, and the virion contains 1.4 X 10(6) daltons of DNA. Denaturation and renaturation studies indicate that the viral genome is a single-stranded DNA molecule and that each virion contains either a minus or a plus strand. Upon extraction, the minus and plus strands unite to form double-stranded DNA molecules with no obvious excess of unpaired strands.
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The products of replication are DNA genomes of positive and negative polarity that are packaged into AAV virions with equal frequency.
“The products of the replication are DNA genomes of positive and negative polarity that are packaged into the AAV virions with equal frequency [48].”
From Understanding Capsid Assembly and Genome Packaging for Adeno-Associated Viruses (2017) · cites this paper as [48]
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Berns, K. I., & Adler, S. (1972) · Journal of Virology · doi:10.1128/jvi.9.2.394-396.1972 · Cited by 101 · see citing works
Understanding Capsid Assembly and Genome Packaging for Adeno-Associated Viruses
Bennett, A., Mietzsch, M., & Agbandje-McKenna, M. (2017) · Future Virology · doi:10.2217/fvl-2017-0011 · Cited by 82 · see citing works
- Authors
- Mayor, H. D., Torikai, K., Melnick, J. L., & Mandel, M.
- Affiliations
- Baylor College of Medicine (US)
- The University of Texas MD Anderson Cancer Center (US)
- Venue
- Science
- Published
- 1969-12-05
- Volume
- 166
- Issue
- 3910
- Pages
- 1280-1282
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036811551
- Cited by
- 100
- References
- 0
- Citations by year
- 2024: 4 · 2023: 4 · 2021: 2 · 2020: 2 · 2017: 2 · 2012: 1
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- satellite viruses, single-stranded DNA, viral genome, viral DNA packaging
- MeSH terms
- Adenoviridae, Centrifugation, Density Gradient, DNA, Viral, Microscopy, Electron, Molecular Weight, Nucleic Acid Denaturation, Satellite Viruses, Spectrum Analysis
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