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Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia
Abstract
Molecular cloning of the t(10;14)(q24;q11) recurrent breakpoint of T cell acute lymphoblastic leukemia has demonstrated a transcript for the candidate gene TCL3. Characterization of this gene from chromosome segment 10q24 revealed it to be a new homeobox, HOX11. The HOX11 homeodomain is most similar to that of the murine gene Hlx and possesses a markedly glycine-rich variable region and an acidic carboxyl terminus. HOX11, while expressed in liver, was not detected in normal thymus or T cells. This lineage-restricted homeobox gene is deregulated upon translocation into the T cell receptor locus where it may act as an oncogene.
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Self-citationSegmental distribution of bithorax complex proteins during Drosophila development
Beachy, P. A., Helfand, S. L., & Hogness, D. S. (1985) · Nature · doi:10.1038/313545a0 · Cited by 413
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Inaba, H., Greaves, M., & Mullighan, C. G. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62187-4 · Cited by 1,074
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Liu, Y., Easton, J., Shao, Y., Maciaszek, J., Wang, Z., Wilkinson, M. R., McCastlain, K., Edmonson, M., Pounds, S. B., Shi, L., et al. (2017) · Nature Genetics · doi:10.1038/ng.3909 · Cited by 918
Pear, W. S., Aster, J. C., Scott, M. L., Hasserjian, R. P., Soffer, B., Sklar, J., & Baltimore, D. (1996) · The Journal of experimental medicine · doi:10.1084/jem.183.5.2283 · Cited by 709
Chromosome Aberrations and Cancer
Solomon, E., Borrow, J., & Goddard, A. D. (1991) · Science · doi:10.1126/science.1957167 · Cited by 584
Metadata
- Authors
- Hatano, M., Roberts, C. W. M., Minden, M., Crist, W. M., & Korsmeyer, S. J.
- Venue
- Science
- Published
- 1991-07-05
- Volume
- 253
- Issue
- 5015
- Pages
- 79-82
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1991615434
- Cited by
- 404
- References
- 2
- FWCI
- 35.98
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hatano, M., Roberts, C. W. M., Minden, M., Crist, W. M., & Korsmeyer, S. J. (1991). Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia. Science. https://doi.org/10.1126/science.1676542
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