Segmental distribution of bithorax complex proteins during Drosophila development

Beachy, Philip A.; Helfand, Stephen L.; Hogness, David S.

doi:10.1038/313545a0

Cited by 414Genomics and Chromatin DynamicsDevelopmental Biology and Gene RegulationEpigenetics and DNA Methylation

Segmental distribution of bithorax complex proteins during Drosophila development

Beachy, Philip A., Helfand, Stephen L., Hogness, David S.·1985·Nature

DOI 10.1038/313545a0

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Abstract

The Ubx and bxd transcription units comprise a single functional domain in the bithorax complex of Drosophila melanogaster. The segmental distributions and nuclear localization of proteins encoded by the Ubx unit have been determined by immunofluorescence staining with antibodies raised against a fusion protein containing Ubx coding sequences. Wild-type and mutant distributions are consistent with a model in which the protein-coding functions of the domain derive from the Ubx unit and are regulated by the bxd unit.

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Microexons, defined as 3-27 nucleotide exons, have been largely missed by genome annotations and transcriptome profiling studies, especially those shorter than 15 nucleotides.
“In particular, microexons (Beachy et al., 1985; Coleman et al., 1987), defined here as 3-27 nucleotide (nt)-long exons, have been largely missed by genome annotations and transcriptome profiling studies (Volfovsky et al., 2003; Wu et al., 2013; Wu and Watanabe, 2005). This is especially true for microexons shorter than 15 nts.”
From A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains (2014) · cites this paper as Beachy et al., 1985

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Authors: Beachy, P. A., Helfand, S. L., & Hogness, D. S.
Affiliations: Stanford Medicine (US)
ORCID: Beachy, Philip A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1985-02
Volume: 313
Issue: 6003
Pages: 545-551
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/313545a0
OpenAlex: W2041519679
Cited by: 413
References: 51
Citations by year: 2026: 3 · 2025: 1 · 2024: 2 · 2023: 14 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 4
FWCI: 23.20
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: bithorax complex, Ubx, Drosophila melanogaster, developmental gene expression, nuclear localization, homeotic genes, transcriptional regulation, segmental distribution
MeSH terms: Animals, Antibodies, Base Sequence, Cell Nucleus, Drosophila melanogaster, Fluorescent Antibody Technique, Gene Expression Regulation, Larva, Models, Genetic, Morphogenesis, Transcription Factors, Transcription, Genetic

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Segmental distribution of bithorax complex proteins during Drosophila development

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