The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Reactions of Alpha Methylene Lactone Tumor Inhibitors with Model Biological Nucleophiles
Abstract
Thiols are the most reactive nucleophilic reagents among the biological models investigated. They undergo "Michael-type" addition to the polyfunctional sesquiterpene lactones. The rapid rates of reaction with L-cysteine were measured and the reaction products were characterized. Each addition of thiol successively decreased the cytotoxicity of the adducts formed.
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Citations
Cites
Determination of sulfhydryl groups with 2,2′- or 4,4′-dithiodipyridine
Grassetti, D. R., & Murray, J. F. (1967) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(67)90426-2 · Cited by 989
Thiol Groups of Biological Importance
Barron, E. S. G. (1951) · Advances in Enzymology - and Related Areas of Molecular Biology · doi:10.1002/9780470122563.ch4 · Cited by 225
Antineoplastic Principles in Plants: Recent Developments in the Field
Hartwell, J. L., & Abbott, B. J. (1970) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60561-x · Cited by 141
Kinetics of the reaction of N-ethylmaleimide with cysteine and some congeners
Gorin, G., Martic, P. A., & Doughty, G. (1966) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(66)90079-8 · Cited by 123
Carcinogenicity of lactones. III. The reactions of unsaturated .gamma.-lactones with L-cysteine
Jones, J. B., & Young, J. M. (1968) · Journal of Medicinal Chemistry · doi:10.1021/jm00312a017 · Cited by 59
Cited by
What made sesquiterpene lactones reach cancer clinical trials?
Ghantous, A., Gali-Muhtasib, H., Vuorela, H., Saliba, N. A., & Darwiche, N. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.06.002 · Cited by 615
Jackson, P. A., Widen, J. C., Harki, D. A., & Brummond, K. M. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00788 · Cited by 588
Metadata
- Authors
- Kupchan, S. M., Fessler, D. C., Eakin, M. A., & Giacobbe, T. J.
- Venue
- Science
- Published
- 1970-04-17
- Volume
- 168
- Issue
- 3929
- Pages
- 376-378
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982791868
- Cited by
- 298
- References
- 5
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kupchan, S. M., Fessler, D. C., Eakin, M. A., & Giacobbe, T. J. (1970). Reactions of Alpha Methylene Lactone Tumor Inhibitors with Model Biological Nucleophiles. Science. https://doi.org/10.1126/science.168.3929.376
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
