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Polypeptide with Broad Biological Activity: Isolation from Small Intestine
Abstract
A polypeptide, which has potent and diverse biological action—including systemic vasodilation, hypotension, increased cardiac output, respiratory stimulation, and hyperglycemia—was isolated from the small intestine of the hog. The peptide has 28 amino acid residues and is chemically distinct from the kinins, "substance P," glucagon, and secretin.
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Cited by
Prolactin: structure, function, and regulation of secretion
Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740
Agrawal, M., Saraf, S., Saraf, S., Antimisiaris, S. G., Chougule, M. B., Shoyele, S. A., & Alexander, A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.011 · Cited by 630
Ovulation: Parallels With Inflammatory Processes
Duffy, D. M., Ko, C., Jo, M., Brannstrom, M., & Curry, T. E. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00075 · Cited by 513
Vasoactive intestinal polypeptide (VIP) in mouse and rat brain: An immunocytochemical study
Sims, K. B., Hoffman, D. L., Said, S. I., & Zimmerman, E. A. (1980) · Brain Research · doi:10.1016/0006-8993(80)90263-2 · Cited by 396
Self-citation
Metadata
- Authors
- Said, S. I., & Mutt, V.
- Venue
- Science
- Published
- 1970-09-18
- Volume
- 169
- Issue
- 3951
- Pages
- 1217-1218
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2032350393
- Cited by
- 1,596
- References
- 0
- FWCI
- 4.10
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
