Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

The Physiology of Reproduction

Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,879 · see citing works

TGF-β SIGNAL TRANSDUCTION

Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571 · see citing works

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501 · see citing works

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878 · see citing works

Phototransduction by retinal ganglion cells that set the circadian clock

Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629 · see citing works

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

Brazeau, P., Vale, W., Burgus, R. C., LING, N. C., Butcher, M., Rivier, J., & Guillemin, R. (1973) · Science · doi:10.1126/science.179.4068.77 · Cited by 3,536 · see citing works

Neurons containing hypocretin (orexin) project to multiple neuronal systems

Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466 · see citing works

Narcolepsy in orexin Knockout Mice

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095 · see citing works

The oxytocin receptor system: structure, function, and regulation

Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works

Psychopharmacology: The Fourth Generation of Progress

Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985 · see citing works

Molecular Bases for Circadian Clocks

Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900 · see citing works

Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity

Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734 · see citing works

FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE

FALCK, B., Hillarp, N. ‐., THIEME, G., & Torp, A. (1962) · Journal of Histochemistry & Cytochemistry · doi:10.1177/10.3.348 · Cited by 2,697 · see citing works

Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide

Tatemoto, K., Carlquist, M., & Mutt, V. (1982) · Nature · doi:10.1038/296659a0 · Cited by 2,254 · see citing works

A functional analysis of circadian pacemakers in nocturnal rodents

Pittendrigh, C. S., & Daan, S. (1976) · Journal of Comparative Physiology A · doi:10.1007/bf01417856 · Cited by 2,129 · see citing works

Calcitonin gene-related peptide is a potent vasodilator

Brain, S. D., Williams, T. J., Tippins, J. R., Morris, H. R., & MacIntyre, I. M. (1985) · Nature · doi:10.1038/313054a0 · Cited by 2,086 · see citing works

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001 · see citing works

Resetting central and peripheral circadian oscillators in transgenic rats

Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907 · see citing works

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853 · see citing works

Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells

Miyata, A., Arimura, A., Dahl, R. R., Minamino, N., Uehara, A., Jiang, L., Culler, M. D., & Coy, D. H. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)91757-9 · Cited by 1,831 · see citing works

ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES 1

Lerner, A. B., Case, J. D., TAKAHASHI, Y., Lee, T. H., & Mori, W. (1958) · Journal of the American Chemical Society · doi:10.1021/ja01543a060 · Cited by 1,759 · see citing works

Suprachiasmatic nucleus : the mind's clock

Klein, D. C., Moore, R. Y., & Reppert, S. M. (1991) · Cited by 1,713 · see citing works

A functional analysis of circadian pacemakers in nocturnal rodents: V. Pacemaker structure: A clock for all seasons

Pittendrigh, C. S., & Daan, S. (1976) · Journal of Comparative Physiology ? A · doi:10.1007/bf01417860 · Cited by 1,636 · see citing works

mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop

Kume, K., Zylka, M. J., Sriram, S., Shearman, L. P., Weaver, D. R., Jin, X., Maywood, E. S., Hastings, M. H., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)81014-4 · Cited by 1,617 · see citing works

Polypeptide with Broad Biological Activity: Isolation from Small Intestine

Said, S. I., & Mutt, V. (1970) · Science · doi:10.1126/science.169.3951.1217 · Cited by 1,603 · see citing works

An unidentified depressor substance in certain tissue extracts

von Euler, U. S., & Gaddum, J. H. (1931) · The Journal of Physiology · doi:10.1113/jphysiol.1931.sp002763 · Cited by 1,584 · see citing works

Melatonin in Humans

Brzezinski, A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701163360306 · Cited by 1,549 · see citing works

Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms.

Welsh, D. K., Logothetis, D., Meister, M., & Reppert, S. (1995) · Neuron · doi:10.1016/0896-6273(95)90214-7 · Cited by 1,535 · see citing works

Handbuch der Mikroskopischen Anatomie des Menschen

Möllendorff, W. V., & Bargmann, W. (1958) · Springer eBooks · doi:10.1007/978-3-662-30619-2 · Cited by 1,516 · see citing works

Molecular analysis of mammalian circadian rhythms

Reppert, S. M., & Weaver, D. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.647 · Cited by 1,444 · see citing works

Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals

Ljungdahl, Å., Hökfelt, T. G. M., & Nilsson, G. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90116-1 · Cited by 1,434 · see citing works

The Pineal and Its Hormones in the Control of Reproduction in Mammals*

Reiter, R. J. (1980) · Endocrine Reviews · doi:10.1210/edrv-1-2-109 · Cited by 1,254 · see citing works

Differential signal transduction by five splice variants of the PACAP receptor

Spengler, D., Waeber, C., Pantaloni, C., Holsboer, F., Bockaert, J., Seeburg, P. H., & Journot, L. (1993) · Nature · doi:10.1038/365170a0 · Cited by 1,182 · see citing works

Actions of Melatonin in the Reduction of Oxidative Stress

Reiter, R. J., Tan, D. X., Osuna, C., & Gitto, E. (2000) · Journal of Biomedical Science · doi:10.1007/bf02253360 · Cited by 1,182 · see citing works

Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways

Bading, H., Ginty, D. D., & Greenberg, M. E. (1993) · Science · doi:10.1126/science.8097060 · Cited by 1,157 · see citing works

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions

Vaudry, D., Gonzalez, B. J., Basille, M., Yon, L., Fournier, A., & Vaudry, H. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01449-2 · Cited by 1,120 · see citing works

Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses

Reppert, S. M., Weaver, D. R., & Ebisawa, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90055-8 · Cited by 1,096 · see citing works

The anatomy of neuropeptide-y-containing neurons in rat brain

Chronwall, B. M., DiMaggio, D. A., Massari, V. J., Pickel, V. M., Ruggiero, D. A., & O’Donohue, T. L. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90260-x · Cited by 1,088 · see citing works

Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat

Wada, E., Wada, K., Boulter, J., Deneris, E. S., Heinemann, S., Patrick, J., & Swanson, L. W. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902840212 · Cited by 1,044 · see citing works

Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat

Buijs, R. M., Swaab, D. F., Dogterom, J., & van Leeuwen, F. W. (1978) · Cell and Tissue Research · doi:10.1007/bf00224932 · Cited by 1,029 · see citing works

The melatonin rhythm: both a clock and a calendar

Reiter, R. J. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923947 · Cited by 997 · see citing works

Leptin: The Tale of an Obesity Gene

Caro, J. F., Sinha, M. K., Kolaczynski, J. W., Zhang, P. L., & Considine, R. V. (1996) · Diabetes · doi:10.2337/diab.45.11.1455 · Cited by 982 · see citing works

XVI. International Union of Pharmacology Recommendations for the Nomenclature of Neuropeptide Y, Peptide YY, and Pancreatic Polypeptide Receptors

Michel, M. C., Beck‐Sickinger, A. G., Cox, H. M., Doods, H. N., Herzog, H., Larhammar, D., Quirion, R., Schwartz, T. W., & Westfall, T. C. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01352-8 · Cited by 896 · see citing works

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

Jin, X., Shearman, L. P., Weaver, D. R., Zylka, M. J., Vries, G. J. D., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80959-9 · Cited by 891 · see citing works

Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.

Reppert, S. M., Godson, C., Mahle, C. D., Weaver, D. R., Slaugenhaupt, S. A., & Gusella, J. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8734 · Cited by 882 · see citing works

Aromatic l-Amino Acid Decarboxylase

Lovenberg, W. M., Weissbach, H., & Udenfriend, S. (1962) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81366-7 · Cited by 854 · see citing works

Serotonin neurons of the midbrain raphe: Ascending projections

Moore, R. Y., Halaris, A. E., & Jones, B. E. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901800302 · Cited by 803 · see citing works

Melatonin and the Mammalian Pineal Gland

Arendt, J. (1994) · Cited by 796 · see citing works

A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms

Silver, R., LeSauter, J., Tresco, P. A., & Lehman, M. N. (1996) · Nature · doi:10.1038/382810a0 · Cited by 792 · see citing works

Amino-acid Sequence of Substance P

CHANG, M. M., Leeman, S. E., & Niall, H. D. (1971) · Nature New Biology · doi:10.1038/newbio232086a0 · Cited by 790 · see citing works

Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus

Akhtar, R. A., Reddy, A. B., Maywood, E. S., Clayton, J. D., King, V. M., Smith, A. G., Gant, T. W., Hastings, M. H., & Kyriacou, C. P. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00759-5 · Cited by 777 · see citing works

The Pineal Gland

Wurtman, R. J., & Axelrod, J. (1965) · Scientific American · doi:10.1038/scientificamerican0765-50 · Cited by 774 · see citing works

Mammalian Photoperiodic System: Formal Properties and Neuroendocrine Mechanisms of Photoperiodic Time Measurement

Goldman, B. D. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129001980 · Cited by 771 · see citing works

International Union of Pharmacology. XVIII. Nomenclature of Receptors for Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide

Harmar, A. J., Arimura, A., Gozes, I., et al. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01360-7 · Cited by 769 · see citing works

Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.

Yamada, Y., Post, S. R., Wang, K., Tager, H. S., Bell, G. I., & Seino, S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.251 · Cited by 753 · see citing works

Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N -Acetyltransferase

Klein, D. C., & Weller, J. L. (1970) · Science · doi:10.1126/science.169.3950.1093 · Cited by 750 · see citing works

Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide

Ishihara, T., Shigemoto, R., Mori, K., Takahashi, K., & Nagata, S. (1992) · Neuron · doi:10.1016/0896-6273(92)90101-i · Cited by 745 · see citing works

The Origin and Function of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)/Glucagon Superfamily

Sherwood, N. M., Krueckl, S. L., & McRory, J. E. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0414 · Cited by 727 · see citing works

Circadian Rhythms in Cultured Mammalian Retina

Tosini, G., & Menaker, M. (1996) · Science · doi:10.1126/science.272.5260.419 · Cited by 716 · see citing works

Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve

Lewy, A. J., Ahmed, S., Jackson, J. M. L., & Sack, R. L. (1992) · Chronobiology International · doi:10.3109/07420529209064550 · Cited by 693 · see citing works

Circadian rhythms in isolated brain regions

Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00350.2002 · Cited by 681 · see citing works

Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity

Moore, R. Y., & Klein, D. C. (1974) · Brain Research · doi:10.1016/0006-8993(74)90188-7 · Cited by 678 · see citing works

Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides

Tatemoto, K., & Mutt, V. (1980) · Nature · doi:10.1038/285417a0 · Cited by 663 · see citing works

Radioimmunoassay of Serum Concentrations of Melatonin in Sheep Exposed to Different Lighting Regimens

Rollag, M. D., & Niswender, G. D. (1976) · Endocrinology · doi:10.1210/endo-98-2-482 · Cited by 643 · see citing works

Receptors and antagonists for substance P and related peptides.

Regoli, D. C., Boudon, A., & Fauchère, J. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06810-3 · Cited by 633 · see citing works

Structure and expression of a human oxytocin receptor

Kimura, T., Tanizawa, O., Mori, K., Brownstein, M., & Okayama, H. (1992) · Nature · doi:10.1038/356526a0 · Cited by 631 · see citing works

Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides

Wahlestedt, C., Yanaihara, N., & Håkanson, R. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90048-0 · Cited by 630 · see citing works

Melatonin: A Coordinating Signal for Mammalian Reproduction?

Tamarkin, L., Baird, C. J., & Almeida, O. F. X. (1985) · Science · doi:10.1126/science.3881822 · Cited by 630 · see citing works

Melatonin receptors: Localization, molecular pharmacology and physiological significance

Morgan, P. J., Barrett, P., Howell, H. E., & Helliwell, R. J. A. (1994) · Neurochemistry International · doi:10.1016/0197-0186(94)90100-7 · Cited by 623 · see citing works

Identification of the Melatonin-binding SiteMT 3 as the Quinone Reductase 2

Nosjean, O., Ferro, M., Cogé, F., Beauverger, P., Henlin, J., Lefoulon, F., Fauchère, J., Delagrange, P., Canet, E., & Boutin, J. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005141200 · Cited by 604 · see citing works

Distribution, properties, and functional characteristics of three classes of histamine receptor.

Hill, S. J. (1990) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00039-0 · Cited by 591 · see citing works

Pineal N-acetyltransferase and hydroxyindole-O-methyl-transferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus

Klein, D. C., & Moore, R. Y. (1979) · Brain Research · doi:10.1016/0006-8993(79)90848-5 · Cited by 583 · see citing works

Hypothalamic integration of central and peripheral clocks

Buijs, R. M., & Kalsbeek, A. (2001) · Nature reviews. Neuroscience · doi:10.1038/35081582 · Cited by 580 · see citing works

Cellular Mechanisms of Melatonin Action

Vaněček, J. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.3.687 · Cited by 579 · see citing works

Minireview: Ghrelin and the Regulation of Energy Balance--A Hypothalamic Perspective

Horváth, T. L., Diano, S., Sótonyi, P., Heiman, M. L., & Tschöp, M. H. (2001) · Endocrinology · doi:10.1210/endo.142.10.8490 · Cited by 570 · see citing works

The development, topographical relations and innervation of the epiphysis cerebri in the albino rat

Kappers, J. A. (1960) · Cell and Tissue Research · doi:10.1007/bf00338980 · Cited by 568 · see citing works

GABA is the principal neurotransmitter of the circadian system

Moore, R. Y., & Speh, J. C. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90120-a · Cited by 555 · see citing works

Free-Running Activity Rhythms in the Rat: Entrainment by Melatonin

Redman, J., Armstrong, S., & Ng, K. T. (1983) · Science · doi:10.1126/science.6823571 · Cited by 551 · see citing works

Molecular Genetics of Circadian Rhythms in Mammals

King, D. P., & Takahashi, J. S. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.713 · Cited by 551 · see citing works

The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland.

Klein, D. C., Coon, S. L., Roseboom, P. H., Weller, J. L., Bernard, M., Gastel, J. A., Zatz, M., Iuvone, P. M., Rodríguez, I. R., Bégay, V., et al. (1997) · PubMed · Cited by 550 · see citing works

Alzheimer's β-Amyloid Peptides Compete for Insulin Binding to the Insulin Receptor

Xie, L., Helmerhorst, E., Taddei, K., Plewright, B., van Bronswijk, W., & Martins, R. N. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-10-j0001.2002 · Cited by 542 · see citing works

Regulation of Daily Locomotor Activity and Sleep by Hypothalamic EGF Receptor Signaling

Kramer, A., Yang, F.-C., Snodgrass, P., Li, X., Scammell, T. E., Davis, F. C., & Weitz, C. J. (2001) · Science · doi:10.1126/science.1067716 · Cited by 536 · see citing works

Retinopathy and attenuated circadian entrainment in Crx-deficient mice

Furukawa, T., Morrow, E. M., Li, T., Davis, F. C., & Cepko, C. L. (1999) · Nature Genetics · doi:10.1038/70591 · Cited by 534 · see citing works

The timed infusion paradigm for melatonin delivery: What has it taught us about the melatonin signal, its reception, and the photoperiodic control of seasonal responses?

Badness, T. J., Powers, J. B., Hastings, M. H., Bittman, E. L., & Goldman, B. D. (1993) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1993.tb00903.x · Cited by 531 · see citing works

Regulation of the Mammalian Pineal by Non-rod, Non-cone, Ocular Photoreceptors

Lucas, R. J., Freedman, M. S., Muñoz, M., García-Fernández, J. M., & Foster, F. (1999) · Science · doi:10.1126/science.284.5413.505 · Cited by 525 · see citing works

Cloning and characterization of a vasopressin V2 receptor and possible link to nephrogenic diabetes insipidus

Lolait, S. J., O'Carroll, A.-M., McBride, O. W., Konig, M., Morel, A., & Brownstein, M. J. (1992) · Nature · doi:10.1038/357336a0 · Cited by 524 · see citing works

Melatonin is a potent modulator of dopamine release in the retina

Dubocovich, M. L. (1983) · Nature · doi:10.1038/306782a0 · Cited by 512 · see citing works

The VIP2 receptor: Molecular characterisation of a cDNA encoding a novel receptor for vasoactive intestinal peptide

Lutz, E. M., Sheward, W. J., West, K. M., Morrow, J. A., Fink, G., & Harmar, A. J. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81668-p · Cited by 497 · see citing works

Calcitonin Gene-Related Peptide and Its Receptors: Molecular Genetics, Physiology, Pathophysiology, and Therapeutic Potentials

Wimalawansa, S. J. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-5-533 · Cited by 494 · see citing works

The immunocytochemical localization of somatostatin-containing neurons in the rat central nervous system

Finley, J. C. W., Maderdrut, J. L., ROGER, L. J., & Petrusz, P. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90006-3 · Cited by 491 · see citing works

Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway

Buijs, R. M., Wortel, J., Van Heerikhuize, J. J., Feenstra, M. G. P., Ter Horst, G. J., Romijn, H. J., & Kalsbeek, A. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00575.x · Cited by 485 · see citing works

Molecular cloning and expression of a rat Via arginine vasopressin receptor

Morel, A., O'Carroll, A.-M., Brownstein, M. J., & Lolaft, S. J. (1992) · Nature · doi:10.1038/356523a0 · Cited by 477 · see citing works

Tryptophan Hydroxylation: Measurement in Pineal Gland, Brainstem, and Carcinoid Tumor

Lovenberg, W. M., Jéquier, E., & Sjoerdsma, A. (1967) · Science · doi:10.1126/science.155.3759.217 · Cited by 471 · see citing works

Melatonin and Its Relation to the Immune System and Inflammation

Reiter, R. J., Calvo, J. R., Karbownik‐Lewińska, M., Qi, W., & TAN, D. X. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05402.x · Cited by 464 · see citing works

The Pineal Organ

Vollrath, L. (1981) · Handbuch der mikroskopischen Anatomie des Menschen · doi:10.1007/978-3-642-81525-6 · Cited by 458 · see citing works

Mammalian melatonin receptors: molecular biology and signal transduction

von Gall, C., Stehle, J. H., & Weaver, D. R. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0581-4 · Cited by 455 · see citing works

Fluctuation of extracellular hypocretin‐1 (orexin A) levels in the rat in relation to the light–dark cycle and sleep–wake activities

Yoshida, Y., Fujiki, N., Nakajima, T., Ripley, B. A., Matsumura, H., Yoneda, H., Mignot, E. J.-M., & Nishino, S. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01725.x · Cited by 449 · see citing works

Localization and pharmacological characterization of high affinity binding sites for vasopressin and oxytocin in the rat brain by light microscopic autoradiography

Tribollet, E., Barberis, C., Jard, S., Dubois-Dauphin, M., & Dreifuss, J. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)91437-0 · Cited by 442 · see citing works

Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture.

Hill, S. M., & Blask, D. E. (1988) · PubMed · Cited by 442 · see citing works

Enzymatic O-Methylation of N-Acetylserotonin to Melatonin

Axelrod, J., & Weissbach, H. (1960) · Science · doi:10.1126/science.131.3409.1312 · Cited by 437 · see citing works

Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P

Lee, Y., Takami, K., Kawai, Y., Girgis, S. I., Hillyard, C. J., MacIntyre, I. M., Emson, P. C., & Tohyama, M. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90265-9 · Cited by 437 · see citing works

Cloned human neuropeptide Y receptor couples to two different second messenger systems.

Herzog, H., Hort, Y. J., Ball, H. J., Hayes, G. R., Shine, J., & SELBIE, L. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5794 · Cited by 434 · see citing works

Melatonin Synthesis in the Pineal Gland: Control by Light

Wurtman, R. J., Axelrod, J., & Phillips, L. S. (1963) · Science · doi:10.1126/science.142.3595.1071 · Cited by 433 · see citing works

Melatonin receptors step into the light: cloning and classification of subtypes

Reppart, S. M., Weaver, D. R., & Godson, C. (1996) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(96)10005-5 · Cited by 426 · see citing works

Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes

Sugden, D., Vaněček, J., Klein, D. C., et al. (1985) · Nature · doi:10.1038/314359a0 · Cited by 412 · see citing works

LOCOMOTOR ACTIVITY AND NON‐PHOTIC INFLUENCES ON CIRCADIAN CLOCKS

Mrosovsky, N. (1996) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1996.tb01278.x · Cited by 412 · see citing works

Purification and Properties of Hydroxyindole-O-methyl Transferase

Axelrod, J., & Weissbach, H. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64458-8 · Cited by 410 · see citing works

Sensitive assay for serotonin N-acetyltransferase activity in rat pineal

Deguchi, T., & Axelrod, J. (1972) · Analytical Biochemistry · doi:10.1016/0003-2697(72)90496-4 · Cited by 408 · see citing works

Effect of Melatonin on the Reproductive Systems of Male and Female Syrian Hamsters: A Diurnal Rhythm in Sensitivity to Melatonin12

Tamarkin, L., Westrom, W. K., HAMILL, A. I., & Goldman, B. D. (1976) · Endocrinology · doi:10.1210/endo-99-6-1534 · Cited by 404 · see citing works

Hypothalamic melatonin receptor sites revealed by autoradiography

Vaněček, J., Pavlík, A., & Illnerová, H. (1987) · Brain Research · doi:10.1016/0006-8993(87)91625-8 · Cited by 401 · see citing works

Adrenergic signals direct rhythmic expression of transcriptional represser CREM in the pineal gland

Stehle, J. H., Foulkes, N. S., Molina, C. A. F., et al. (1993) · Nature · doi:10.1038/365314a0 · Cited by 399 · see citing works

Antigonadal Effects of Timed Melatonin Infusion in Pinealectomized Male Djungarian Hamsters (Phodopus sungorus sungorus): Duration is the Critical Parameter*

Carter, D. S., & Goldman, B. D. (1983) · Endocrinology · doi:10.1210/endo-113-4-1261 · Cited by 393 · see citing works

Crystal Structure of the 14-3-3ζ:Serotonin N-Acetyltransferase Complex

Obšil, T., Ghirlando, R., Klein, D. C., Ganguly, S., & Dyda, F. (2001) · Cell · doi:10.1016/s0092-8674(01)00316-6 · Cited by 389 · see citing works

Neural control of the pineal gland

Moore, R. Y. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00083-6 · Cited by 385 · see citing works

Control of Hydroxyindole O-Methyltransferase Activity in the Rat Pineal Gland by Environmental Lighting

Axelrod, J., Wurtman, R. J., & Snyder, S. H. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45266-5 · Cited by 380 · see citing works

Central effects of oxytocin

Richard, P., Moos, F., & Freund-Mercier, M. J. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.2.331 · Cited by 379 · see citing works

The Origin and Function of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)/Glucagon Superfamily

Sherwood, N. M. (2000) · Endocrine Reviews · doi:10.1210/er.21.6.619 · Cited by 378 · see citing works

Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor.

Sugimoto, T., Saito, M., Mochizuki, S., Watanabe, Y., Hashimoto, S., & Kawashima, H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47129-3 · Cited by 376 · see citing works

The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226

Rudolf, K. D., Eberlein, W. G., Engel, W. W., Wieland, H., Willim, K., Entzeroth, M., Wienen, W., Beck‐Sickinger, A. G., & Doods, H. N. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90822-2 · Cited by 375 · see citing works

[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist.

Fuhlendorff, J., Gether, U., Aakerlund, L., Johansen, N. L., Thøgersen, H., Melberg, S., Olsen, U. B., Thastrup, M., & Schwartz, T. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.182 · Cited by 375 · see citing works

Biology of Mammalian Photoperiodism and the Critical Role of the Pineal Gland and Melatonin

Malpaux, B., Migaud, M., Tricoire-Leignel, H., & Chemineau, P. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129002051 · Cited by 371 · see citing works

Photoneural Regulation of the Mammalian Pineal Gland

Klein, D. C. (1985) · Novartis Foundation symposium · doi:10.1002/9780470720981.ch4 · Cited by 364 · see citing works

Central functions of oxytocin

Argiolas, A., & GESSA, G. L. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80002-8 · Cited by 364 · see citing works

Circadian rhythm in rat pineal serotonin and its modifications by estrous cycle and photoperiod

Quay, W. B. (1963) · General and Comparative Endocrinology · doi:10.1016/0016-6480(63)90079-0 · Cited by 360 · see citing works

Rapid Light-Induced Decrease in Pineal Serotonin N -Acetyltransferase Activity

Klein, D. C., & Weller, J. L. (1972) · Science · doi:10.1126/science.177.4048.532 · Cited by 358 · see citing works

Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization

Menéndez-Peláez, A., & Reiter, R. J. (1993) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1993.tb00511.x · Cited by 351 · see citing works

The retinohypothalamic tract originates from a distinct subset of retinal ganglion cells

Moore, R. Y., Speh, J. C., & Card, J. P. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903520304 · Cited by 350 · see citing works

Neurochemical organization of the hypothalamic projection to the spinal cord in the rat

Cechetto, D. F., & Saper, C. B. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902720410 · Cited by 346 · see citing works

Pineal Serotonin N -Acetyltransferase: Expression Cloning and Molecular Analysis

Coon, S. L., Roseboom, P. H., Baler, R., et al. (1995) · Science · doi:10.1126/science.270.5242.1681 · Cited by 344 · see citing works

Vasopressin Receptors

Birnbaumer, M. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00304-0 · Cited by 343 · see citing works

The Photopigment Melanopsin Is Exclusively Present in Pituitary Adenylate Cyclase-Activating Polypeptide-Containing Retinal Ganglion Cells of the Retinohypothalamic Tract

Hannibal, J., Hindersson, P., Knudsen, S. M., Georg, B., & Fahrenkrug, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-01-j0002.2002 · Cited by 339 · see citing works

Spinal origin of sympathetic preganglionic neurons in the rat

Strack, A. M., Sawyer, W. B., Marubio, L. M., & Loewy, A. D. (1988) · Brain Research · doi:10.1016/0006-8993(88)90132-1 · Cited by 339 · see citing works

The Fate of Melatonin in Animals

Kopin, I. J., Pare, C. M. B., Axelrod, J., & Weissbach, H. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76431-x · Cited by 338 · see citing works

Extrapituitary expression of the rat V1b vasopressin receptor gene.

Lolait, S. J., O’Carroll, A., Mahan, L. C., Felder, C. C., Button, D. C., Young, W. S., Mezey, É., & Brownstein, M. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6783 · Cited by 337 · see citing works

Circadian Programs of Transcriptional Activation, Signaling, and Protein Turnover Revealed by Microarray Analysis of Mammalian Cells

Duffield, G. E., Best, J. D., Meurers, B. H., Bittner, A., Loros, J., & Dunlap, J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00765-0 · Cited by 329 · see citing works

Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor

Freedman, N. J., Liggett, S. B., Drachman, D. E., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.30.17953 · Cited by 325 · see citing works

Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland.

Roseboom, P. H., Coon, S. L., Baler, R., et al. (1996) · Endocrinology · doi:10.1210/endo.137.7.8770929 · Cited by 317 · see citing works

Role of Cyclic Amp in Cell Function

Greengard, P., & Costa, E. (1970) · Medical Entomology and Zoology · Cited by 315 · see citing works

Melatonin directly resets the rat suprachiasmatic circadian clock in vitro

McArthur, A. J., Gillette, M. U., & Prosser, R. A. (1991) · Brain Research · doi:10.1016/0006-8993(91)91748-p · Cited by 314 · see citing works

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and PACAP/Vasoactive Intestinal Polypeptide Receptors: Actions on the Anterior Pituitary Gland*

Rawlings, S. R., & HEZAREH, M. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-1-4 · Cited by 309 · see citing works

Organization of lateral geniculate‐hypothalamic connections in the rat

Card, J. P., & Moore, R. Y. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902840110 · Cited by 299 · see citing works

The suprachiasmatic nucleus and the circadian time-keeping system revisited

van Esseveldt, L. E., Lehman, M. N., & Boer, G. J. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00025-4 · Cited by 296 · see citing works

Melatonin inhibition and pinealectomy enhancement of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in the rat.

Tamarkin, L., Cohen, M., Roselle, D., Reichert, C. M., Lippman, M. E., & Chabner, B. A. (1981) · PubMed · Cited by 296 · see citing works

Natural melatonin `knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase

Roseboom, P. H., Namboodiri, M. A. A., Zimonjic, D. B., Popescu, N. C., Rodríguez, I. R., Gastel, J. A., & Klein, D. C. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00273-3 · Cited by 295 · see citing works

Ventral lateral geniculate nucleus efferents to the rat suprachiasmatic nucleus exhibit avian pancreatic polypeptide‐like immunoreactivity

Card, J. P., & Moore, R. Y. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902060407 · Cited by 293 · see citing works

GENETICS OF THE MAMMALIAN CIRCADIAN SYSTEM: Photic Entrainment, Circadian Pacemaker Mechanisms, and Posttranslational Regulation

Lowrey, P. L., & Takahashi, J. S. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.533 · Cited by 293 · see citing works

Control of Circadian Change of Serotonin N -Acetyltransferase Activity in the Pineal Organ by the β-Adrenergic Receptor

Deguchi, T., & Axelrod, J. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.9.2547 · Cited by 292 · see citing works

Pituitary Adenylate Cyclase-Activating Peptide (PACAP) in the Retinohypothalamic Tract: A Potential Daytime Regulator of the Biological Clock

Hannibal, J., Ding, J., Chen, D., Fahrenkrug, J., Larsen, P. J., Gillette, M. U., & Mikkelsen, J. D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02637.1997 · Cited by 288 · see citing works

Melatonin Production: Proteasomal Proteolysis in Serotonin N -Acetyltransferase Regulation

Gastel, J. A., Roseboom, P. H., Rinaldi, P. A., et al. (1998) · Science · doi:10.1126/science.279.5355.1358 · Cited by 287 · see citing works

The pineal gland and melatonin in relation to aging: A summary of the theories and of the data

Reiter, R. J. (1995) · Experimental Gerontology · doi:10.1016/0531-5565(94)00045-5 · Cited by 286 · see citing works

Cellular localization of vasopressin V1a receptor messenger ribonucleic acid in adult male rat brain, pineal, and brain vasculature.

Ostrowski, N. L., Lolait, S. J., & Young, W. S. (1994) · Endocrinology · doi:10.1210/endo.135.4.7925112 · Cited by 284 · see citing works

Melatonin administration can entrain the free-running circadian system of blind subjects

Lockley, S. W., Skene, D. J., James, K., Thapan, K., Wright, J., & Arendt, J. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.164r001 · Cited by 284 · see citing works

The anatomy and innervation of the mammalian pineal gland

Møller, M., & Baeres, F. M. M. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0580-5 · Cited by 284 · see citing works

Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.

Yamada, Y., Reisine, T., Law, S. F., et al. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.12.1337145 · Cited by 282 · see citing works

Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor.

Thibonnier, M., Auzan, C., Madhun, Z. T., Wilkins, P. L., Berti‐Mattera, L. N., & Clauser, É. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41863-1 · Cited by 281 · see citing works

Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation

Ganguly, S., Coon, S. L., & Klein, D. C. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0579-y · Cited by 277 · see citing works

Pineal control of aging: effect of melatonin and pineal grafting on aging mice.

Pierpaoli, W., & Regelson, W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.787 · Cited by 276 · see citing works

Some effects of jet-lag and their alleviation by melatonin

Arendt, J., Aldhous, M. E., English, J., Marks, V., Arendt, J., Marks, M., & Folkard, S. (1987) · Ergonomics · doi:10.1080/00140138708966031 · Cited by 276 · see citing works

Neurotransmitters of the retino-hypothalamic tract

Hannibal, J. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0574-3 · Cited by 275 · see citing works

Cloning and Expression of a Novel Neuropeptide Y Receptor

Weinberg, D. H., SIRINATHSINGHJI, D. J. S., Tan, C. P., Shiao, L., Morin, N. R., Rigby, M. R., Heavens, R. H., Rapoport, D. R., BAYNE, M. L., Cascieri, M. A., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.28.16435 · Cited by 275 · see citing works

Nitric oxide induces neurotransmitter release from hippocampal slices

Lónárt, G., Wang, J., & Johnson, K. M. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90759-w · Cited by 270 · see citing works

Secretoneurin—a neuropeptide generated in brain, adrenal medulla and other endocrine tissues by proteolytic processing of secretogranin II (chromogranin C)

Kirchmair, R., Hogue‐Angeletti, R., Gutierrez, J., et al. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90200-y · Cited by 270 · see citing works

Seasonal control of energy requirements for thermoregulation in the djungarian hamster (Phodopus sungorus), living in natural photoperiod

Heldmaier, G., & Steinlechner, S. (1981) · Journal of Comparative Physiology B · doi:10.1007/bf00688972 · Cited by 270 · see citing works

Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland

Borjigin, J., Wang, M. M., & Snyder, S. H. (1995) · Nature · doi:10.1038/378783a0 · Cited by 268 · see citing works

Rapid changes in rat pineal beta-adrenergic receptor: alterations in l-(3H)alprenolol binding and adenylate cyclase.

Kebabian, J. W., Zatz, M., Romero, J. A., & Axelrod, J. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3735 · Cited by 266 · see citing works

Cloning and Functional Expression of a cDNA Encoding a Human Type 2 Neuropeptide Y Receptor

Rose, P. M., FERNANDES, P. B., Lynch, J. S., Frazier, S. T., FISHER, S. M., Kodukula, K., Kienzle, B. K., & Seethala, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.39.22661 · Cited by 265 · see citing works

Biosynthesis of melatonin: enzymic conversion of serotonin to N-acetylserotonin

Weissbach, H., Redfield, B. G., & Axelrod, J. (1960) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(60)90453-4 · Cited by 263 · see citing works

Output pathways of the mammalian suprachiasmatic nucleus: coding circadian time by transmitter selection and specific targeting

Kalsbeek, A., & Buijs, R. M. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0577-0 · Cited by 261 · see citing works

Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype.

Stehle, J. H., Rivkees, S. A., Lee, J. J., et al. (1992) · Molecular Endocrinology · doi:10.1210/mend.6.3.1584214 · Cited by 258 · see citing works

Pituitary adenylate cyclase activating peptide is a sensory neuropeptide: Immunocytochemical and immunochemical evidence

Møller, K., Zhang, Y.-Z., Håkanson, R., Luts, A., Sjölund, B. H., Uddman, R., & Sundler, F. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90018-b · Cited by 257 · see citing works

Melatonin biosynthesis in the mammalian pineal gland

Sugden, D. (1989) · Cellular and Molecular Life Sciences · doi:10.1007/bf01953049 · Cited by 255 · see citing works

The immunotherapeutic potential of melatonin

Maestroni, G. J. M. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.3.467 · Cited by 254 · see citing works

Atypical Synergisticα1- andβ-Adrenergic Regulation of Adenosine 3′,5′-Monophosphate and Guanosine 3′,5′- Monophosphate in Rat Pinealocytes

Vaněček, J., Sugden, D., Weller, J. L., & Klein, D. C. (1985) · Endocrinology · doi:10.1210/endo-116-6-2167 · Cited by 253 · see citing works

Cloning, Functional Expression and Pharmacological Characterization of a Fourth (hSSTR4) and a Fifth (hSSTR5) Human Somatostatin Receptor Subtype

Yamada, Y., Kagimoto, S., Kubota, A., et al. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2122 · Cited by 253 · see citing works

The Pineal Gland and Mammalian Photoperiodism

Goldman, B. D., & Darrow, J. M. (2008) · Neuroendocrinology · doi:10.1159/000123579 · Cited by 251 · see citing works

Rhythmic gene expression in pituitary depends on heterologous sensitization by the neurohormone melatonin

von Gall, C., Garabette, M. L., Kell, C. A., Frenzel, S., Dehghani, F., Schumm‐Draeger, P., Weaver, D. R., Korf, H., Hastings, M. H., & Stehle, J. H. (2002) · Nature Neuroscience · doi:10.1038/nn806 · Cited by 251 · see citing works

Glutamate and aspartate immunoreactivity in hypothalamic presynaptic axons

van den Pol, A. N. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-07-02087.1991 · Cited by 251 · see citing works

Cellular biology of somatostatin receptors

Csaba, Z., & Dournaud, P. (2001) · Neuropeptides · doi:10.1054/npep.2001.0848 · Cited by 250 · see citing works

Pineal Gland: 24-Hour Rhythm in Norepinephrine Turnover

Brownstein, M., & Axelrod, J. (1974) · Science · doi:10.1126/science.184.4133.163 · Cited by 248 · see citing works

Morning and evening circadian oscillations in the suprachiasmatic nucleus in vitro

Jagota, A., de la Iglesia, H. O., & Schwartz, W. J. (2000) · Nature Neuroscience · doi:10.1038/73943 · Cited by 246 · see citing works

Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellum

Pozo, D., Reiter, R. J., Calvo, J. R., & Guerrero, J. M. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00532-x · Cited by 245 · see citing works

Resetting the Biological Clock: Mediation of Nocturnal CREB Phosphorylation via Light, Glutamate, and Nitric Oxide

Ding, J., Faiman, L. E., Hurst, W. J., Kuriashkina, L. R., & Gillette, M. U. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-02-00667.1997 · Cited by 245 · see citing works

Evidences associating pineal gland function with alterations in pigmentation

McCord, C. P., & Allen, F. P. (1917) · Journal of Experimental Zoology · doi:10.1002/jez.1400230108 · Cited by 245 · see citing works

Retinal and pineal hydroxyindole-o-methyl transferase activity in vertebrates

Quay, W. B. (1965) · Life Sciences · doi:10.1016/0024-3205(65)90202-x · Cited by 243 · see citing works

Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide

Larhammar, D. (1996) · Regulatory Peptides · doi:10.1016/0167-0115(96)00110-3 · Cited by 242 · see citing works

Efficacy of Melatonin Treatment in Jet Lag, Shift Work, and Blindness

Arendt, J., Skene, D. J., Middleton, B., Lockley, S. W., & Deacon, S. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200616 · Cited by 239 · see citing works

Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic→ spinal cord circuit in the melatonin rhythm generating system

Klein, D. C., Smoot, R. L., Weller, J. L., Higa, S., Markey, S. P., Creed, G. J., & Jacobowitz, D. M. (1983) · Brain Research Bulletin · doi:10.1016/0361-9230(83)90033-3 · Cited by 236 · see citing works

Identification of a Novel Hypothalamic Neuropeptide Y Receptor Associated with Feeding Behavior

Hu, Y., Bloomquist, B. T., Cornfield, L. J., DeCarr, L. B., Flores-Riveros, J. R., Friedman, L., Jiang, P., Lewis‐Higgins, L., Sadlowski, Y., Schaefer, J. F., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26315 · Cited by 236 · see citing works

Narcolepsy

Siegel, J. M. (1999) · Cell · doi:10.1016/s0092-8674(00)81969-8 · Cited by 235 · see citing works

Diurnal modulation of pacemaker potentials and calcium current in the mammalian circadian clock

Pennartz, C. M. A., de Jeu, M. T. G., Bos, N. P. A., Schaap, J., & Geurtsen, A. M. S. (2002) · Nature · doi:10.1038/nature728 · Cited by 234 · see citing works

Prey-selective neurons in the toad's optic tectum and sensorimotor interfacing: HRP studies and recording experiments

Weerasuriya, A., & Ewert, J. ‐. (1981) · Journal of Comparative Physiology A · doi:10.1007/bf01326828 · Cited by 233 · see citing works

Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters

Weaver, D. R., Liu, C., & Reppert, S. M. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.11.8923472 · Cited by 233 · see citing works

Secretogranin II: Molecular properties, regulation of biosynthesis and processing to the neuropeptide secretoneurin

Fischer‐Colbrie, R., Laslop, A., & Kirchmair, R. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)00060-u · Cited by 232 · see citing works

Circadian rhythmicity in vertebrate retinas: Regulation by a photoreceptor oscillator

Cahill, G. (1995) · Progress in Retinal and Eye Research · doi:10.1016/1350-9462(94)00001-y · Cited by 225 · see citing works

Gonadal hormone actions on the morphology of the vasopressinergic innervation of the adult rat brain

De Vries, G. J., Buijs, R. M., & Sluiter, A. A. (1984) · Brain Research · doi:10.1016/0006-8993(84)91157-0 · Cited by 224 · see citing works

PACAP and glutamate are co-stored in the retinohypothalamic tract

Hannibal, J., Møller, M., Ottersen, O. P., & Fahrenkrug, J. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000306)418:2 · Cited by 224 · see citing works

Use of 2-[125I]iodomelatonin to characterize melatonin binding sites in chicken retina.

Dubocovich, M. L., & Takahashi, J. S. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.11.3916 · Cited by 224 · see citing works

Alternative Splicing in the N-terminal Extracellular Domain of the Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) Receptor Modulates Receptor Selectivity and Relative Potencies of PACAP-27 and PACAP-38 in Phospholipase C Activation

Pantaloni, C., Brabet, P., Bilanges, B., Dumuis, A., Houssami, S., Spengler, D., Bockaert, J., & Journot, L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.22146 · Cited by 223 · see citing works

d -aspartate localizations imply neuronal and neuroendocrine roles

Schell, M. J., Cooper, O. B., & Snyder, S. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.2013 · Cited by 220 · see citing works

Neuropeptides phase shift the mammalian circadian pacemaker

Piggins, H. D., Antle, M. C., & Rusak, B. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05612.1995 · Cited by 219 · see citing works

Autism risk factors: genes, environment, and gene-environment interactions

Chaste, P., & Leboyer, M. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.3/pchaste · Cited by 807 · see citing works

Rhythms of life: circadian disruption and brain disorders across the lifespan

Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works

Abnormal melatonin synthesis in autism spectrum disorders

Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., Anckarsäter, H., Rastam, M., Ståhlberg, O., Gillberg, I. C., Delorme, R., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002016 · Cited by 511 · see citing works

Melatonin, endocrine pancreas and diabetes

Peschke, E. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00519.x · Cited by 309 · see citing works

Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?

Jockers, R., Maurice, P., Boutin, J. A., & Delagrange, P. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.184 · Cited by 293 · see citing works

Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content

Erland, L. A. E., & Saxena, P. K. (2017) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.6462 · Cited by 273 · see citing works

Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis

Gheorghe, C. E., Martin, J. A., Manriquez, F. V., Dinan, T. G., Cryan, J. F., & Clarke, G. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.08.004 · Cited by 212 · see citing works

The possible interplay of synaptic and clock genes in autism spectrum disorders

Bourgeron, T. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.020 · Cited by 185 · see citing works

The circadian basis of mood disorders: Recent developments and treatment implications

Monteleone, P., & Maj, M. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.06.007 · Cited by 185 · see citing works

The mammalian pineal gland: known facts, unknown facets

Maronde, E., & Stehle, J. H. (2007) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2007.03.001 · Cited by 178 · see citing works

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

Mulder, H., Nagorny, C. L. F., Lyssenko, V., & Groop, L. (2009) · Diabetologia · doi:10.1007/s00125-009-1359-y · Cited by 169 · see citing works

The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders

Pagan, C., Delorme, R., Callebert, J., Goubran-Botros, H., Amsellem, F., Drouot, X., Boudebesse, C., Le Dudal, K., Ngo-Nguyen, N., Laouamri, H., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.120 · Cited by 165 · see citing works

Advances in the Research of Melatonin in Autism Spectrum Disorders: Literature Review and New Perspectives

Tordjman, S., Najjar, I., Bellissant, E., Anderson, G., Barburoth, M., Cohen, D., Jaafari, N., Schischmanoff, O., Fagard, R., Lagdas, E., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020508 · Cited by 132 · see citing works

New evidence for a role of melatonin in glucose regulation

Peschke, E., & Mühlbauer, E. (2010) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.09.001 · Cited by 137 · see citing works

The role of melatonin in diabetes: therapeutic implications

Sharma, S., Singh, H., Ahmad, N., Mishra, P., & Tiwari, A. (2015) · Archives of Endocrinology and Metabolism · doi:10.1590/2359-3997000000098 · Cited by 135 · see citing works

Circadian depression: A mood disorder phenotype

Carpenter, J. S., Crouse, J. J., Scott, E. M., Naismith, S. L., Wilson, C., Scott, J., Merikangas, K. R., & Hickie, I. B. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.045 · Cited by 114 · see citing works

Sleep- and circadian rhythm–associated pathways as therapeutic targets in bipolar disorder

Bellivier, F., Geoffroy, P.-A., Etain, B., & Scott, J. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1018822 · Cited by 104 · see citing works

Melatonin Target Proteins: Too Many or Not Enough?

Liu, L., Labani, N., Cecon, E., & Jockers, R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00791 · Cited by 102 · see citing works

The Immune–Pineal Axis: Stress as a Modulator of Pineal Gland Function

Couto‐Moraes, R., Palermo‐Neto, J., & Markus, R. P. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03978.x · Cited by 69 · see citing works

Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders: The melatonin pathway in ADHD

Chaste, P., Clement, N., Botros, H. G., Guillaume, J.-L., Konyukh, M., Pagan, C., Scheid, I., Nygren, G., Anckarsäter, H., Rastam, M., et al. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00902.x · Cited by 67 · see citing works

Evolutionary conservations, changes of circadian rhythms and their effect on circadian disturbances and therapeutic approaches

Palm, D., Uzoni, A., Simon, F., Fischer, M., Coogan, A., Tucha, O., Thome, J., & Faltraco, F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.007 · Cited by 20 · see citing works

On the Significance of the 5-Hydroxytryptamine Stores in Pineal Gland

OWMAN, C. (1968) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61170-9 · Cited by 24 · see citing works

Synaptic ribbons of a mammalian pineal gland circadian changes

Vollrath, L. (1973) · Cell and Tissue Research · doi:10.1007/bf00307386 · Cited by 145 · see citing works

The pineal gland

Litwack, G. (2022) · Hormones · doi:10.1016/b978-0-323-90262-5.00023-8

The Pineal Gland

Norman, A. W., & Henry, H. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-08-091906-5.00016-1 · Cited by 4 · see citing works

[The hypothalamic suprachiasmatic nucleus and pineal gland in the circadian rhythmic organization of mammals].

Xj, Z., Gd, Y., & Qz, Y. (2001) · PubMed · Cited by 1 · see citing works