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Expression of Gene rrg Is Associated with Reversion of NIH 3Tt3 Transformed by LTR-c-H- ras
Abstract
A partial complementary DNA was isolated for a gene ( rrg ) that is normally expressed in mouse NIH 3T3 cells, but is down-regulated after cellular transformation by long terminal repeat (LTR)-activated c-H- ras (LTR-c-H- ras ). This gene was reexpressed in a nontumorigenic persistent revertant cell line created by prolonged treatment of the transformed cells with mouse interferon α/β. Persistent revertants stably transfected with rrg complementary DNA antisense expression vectors appeared transformed, had decreased amounts of rrg messenger RNA, and were tumorigenic in nude mice. Stable transfection with sense constructs did not alter the normal morphology, message level, or nontumorigenicity of the persistent revertant cell line.
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Citations
Cites
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
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The IRF Family Transcription Factors in Immunity and Oncogenesis
Tamura, T., Yanai, H., Savitsky, D., & Taniguchi, T. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090400 · Cited by 1,259
Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell
Kagan, H. M., & Li, W. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10413 · Cited by 954
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Metadata
- Authors
- Contente, S., Kenyon, K., Rimoldi, D., & Friedman, R. M.
- Venue
- Science
- Published
- 1990-08-17
- Volume
- 249
- Issue
- 4970
- Pages
- 796-798
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035722336
- Cited by
- 221
- References
- 1
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Contente, S., Kenyon, K., Rimoldi, D., & Friedman, R. M. (1990). Expression of Gene rrg Is Associated with Reversion of NIH 3Tt3 Transformed by LTR-c-H- ras. Science. https://doi.org/10.1126/science.1697103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
