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Recognition by Elam-1 of the Sialyl-Le x Determinant on Myeloid and Tumor Cells
Abstract
Endothelial leukocyte adhesion molecule-1 (ELAM-1) is an endothelial cell adhesion molecule that allows myeloid cells to attach to the walls of blood vessels adjacent to sites of inflammation. ELAM-1 recognizes the sialyl-Lewis X (sialyl-Le x ) determinant, NeuAcα2-3Galβ1-4(Fucα1-3)GlcNAc-, a granulocyte carbohydrate also found on the surface of some tumor cell lines. Binding of myeloid cells to soluble ELAM-1 is inhibited by a monoclonal antibody recognizing sialyl-Le x or by proteins bearing sialyl-Le x , some of which may participate in humoral regulation of myeloid cell adhesion. Stimulated granulocytes also release an inhibitor of ELAM-1 binding that can be selectively adsorbed by monoclonal antibody to sialyl-Le x .
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Cited by
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Stowell, S. R., Ju, T., & Cummings, R. D. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040438 · Cited by 873
Springer, T. A., & Lasky, L. A. (1991) · Nature · doi:10.1038/349196a0 · Cited by 448
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Metadata
- Authors
- Walz, G., Aruffo, A., Kolanus, W., Bevilacqua, M., & Seed, B.
- Venue
- Science
- Published
- 1990-11-23
- Volume
- 250
- Issue
- 4984
- Pages
- 1132-1135
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2130561621
- Cited by
- 962
- References
- 0
- FWCI
- 34.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Walz, G., Aruffo, A., Kolanus, W., Bevilacqua, M., & Seed, B. (1990). Recognition by Elam-1 of the Sialyl-Le x Determinant on Myeloid and Tumor Cells. Science. https://doi.org/10.1126/science.1701275
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
