Protein Glycosylation in Cancer

Stowell, Sean R.; Ju, Tongzhong; Cummings, Richard D.

doi:10.1146/annurev-pathol-012414-040438

Cited by 873Glycosylation and Glycoproteins ResearchProteoglycans and glycosaminoglycans researchCarbohydrate Chemistry and Synthesis

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Protein Glycosylation in Cancer

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Stowell, Sean R., Ju, Tongzhong, Cummings, Richard D.·2015·Annual Review of Pathology: Mechanisms of Disease

DOI 10.1146/annurev-pathol-012414-040438PMC PMC4396820

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Abstract

Neoplastic transformation results in a wide variety of cellular alterations that impact the growth, survival, and general behavior of affected tissue. Although genetic alterations underpin the development of neoplastic disease, epigenetic changes can exert an equally significant effect on neoplastic transformation. Among neoplasia-associated epigenetic alterations, changes in cellular glycosylation have recently received attention as a key component of neoplastic progression. Alterations in glycosylation appear to not only directly impact cell growth and survival but also facilitate tumor-induced immunomodulation and eventual metastasis. Many of these changes may support neoplastic progression, and unique alterations in tumor-associated glycosylation may also serve as a distinct feature of cancer cells and therefore provide novel diagnostic and even therapeutic targets.

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Authors: Stowell, S. R., Ju, T., & Cummings, R. D.
Affiliations: Departments of 1Pathology and Laboratory Medicine and
Emory University (US)
ORCID: Stowell, Sean R.
Ju, Tongzhong
Cummings, Richard D.
Venue: Annual Review of Pathology: Mechanisms of Disease
Publisher: Annual Reviews
Published: 2015-01-24
Volume: 10
Issue: 1
Pages: 473-510
ISSN: 1553-4006 (ISSN-L)
1553-4014
DOI: 10.1146/annurev-pathol-012414-040438
PMC: PMC4396820
OpenAlex: W2171521392
Cited by: 873
References: 9
Citations by year: 2026: 48 · 2025: 88 · 2024: 100 · 2023: 84 · 2022: 100 · 2021: 102 · 2020: 91 · 2019: 69 · 2018: 70 · 2017: 68 · 2016: 39 · 2015: 12
FWCI: 6.11
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Pathology Mechanisms of Disease (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust
Hemophilia of Georgia
National Institutes of Health (DP5OD019892)
National Blood Foundation
National Heart, Lung, and Blood Institute (P01HL085607)
National Cancer Institute (U01CA168930)
National Institute of General Medical Sciences (R24GM098791, P41GM103694)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
Keywords: protein glycosylation, cancer, oncogenic transformation, epigenetic modifications, tumor progression, tumor immunomodulation, metastasis, tumor-associated glycosylation, diagnostic biomarkers, therapeutic target
MeSH terms: Animals, Cell Transformation, Neoplastic, Glycosylation, Humans, Neoplasm Proteins, Neoplasms, Epigenesis, Genetic

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