The DOI matches its Crossref record.
Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn
Abstract
Antigen is thought to cross-link membrane-bound immunoglobulins (Igs) of B cells, causing proliferation and differentiation or the inhibition of growth. Protein tyrosine kinases are probably involved in signal transduction for cell proliferation and differentiation. The Src-like protein tyrosine kinase Lyn is expressed preferentially in B cells. The Lyn protein and its kinase activity could be coimmunoprecipitated with IgM from detergent lysates. Cross-linking of membrane-bound IgM induced a rapid increase in tyrosine phosphorylation of at least ten distinct proteins of B cells. Thus, Lyn is physically associated with membrane-bound IgM, and is suggested to participate in antigen-mediated signal transduction.
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Citations
Cited by
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
Signal transduction from the extracellular matrix.
Juliano, R. L., & Haskill, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.120.3.577 · Cited by 1,683
Kornberg, L. J., Earp, H. S., Turner, C. E., Prockop, C., & Juliano, R. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8392 · Cited by 699
Takata, M., Sabe, H., Hata, A., Inazu, T., Homma, Y., Nukada, T., Yamamura, H., & Kurosaki, T. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06387.x · Cited by 650
Hatakeyama, M., Kono, T., Kobayashi, N., Kawahara, A., Levin, S. D., Perlmutter, R. M., & Taniguchi, T. (1991) · Science · doi:10.1126/science.2047859 · Cited by 561
Metadata
- Authors
- Yamanashi, Y., Kakiuchi, T., Mizuguchi, J., Yamamoto, T., & Toyoshima, K.
- Venue
- Science
- Published
- 1991-01-11
- Volume
- 251
- Issue
- 4990
- Pages
- 192-194
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077236851
- Cited by
- 453
- References
- 0
- FWCI
- 37.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yamanashi, Y., Kakiuchi, T., Mizuguchi, J., Yamamoto, T., & Toyoshima, K. (1991). Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn. Science. https://doi.org/10.1126/science.1702903
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
