The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Interaction of the IL-2 Receptor with the src -Family Kinase p56 lck : Identification of Novel Intermolecular Association
Abstract
In the interleukin-2 (IL-2) system, intracellular signal transduction is triggered by the β chain of the IL-2 receptor (IL-2Rβ); however, the responsible signaling mechanism remains unidentified. Evidence for the formation of a stable complex of IL-2Rβ and the lymphocyte-specific protein tyrosine kinase p56 lck is presented. Specific association sites were identified in the tyrosine kinase catalytic domain of p56 lck and in the cytoplasmic domain of IL-2Rβ. As a result of interaction, IL-2Rβ became phosphorylated in vitro by p56 lck . Treatment of T lymphocytes with IL-2 promotes p56 lck kinase activity. These data suggest the participation of p56 lck as a critical signaling molecule downstream of IL-2R via a novel interaction.
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Cites
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Cited by
Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor
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Interleukin-6 and its receptor: a paradigm for cytokines
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Metadata
- Authors
- Hatakeyama, M., Kono, T., Kobayashi, N., Kawahara, A., Levin, S. D., Perlmutter, R. M., & Taniguchi, T.
- Venue
- Science
- Published
- 1991-06-14
- Volume
- 252
- Issue
- 5012
- Pages
- 1523-1528
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2047945116
- Cited by
- 561
- References
- 46
- FWCI
- 48.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hatakeyama, M., Kono, T., Kobayashi, N., Kawahara, A., Levin, S. D., Perlmutter, R. M., & Taniguchi, T. (1991). Interaction of the IL-2 Receptor with the src -Family Kinase p56 lck : Identification of Novel Intermolecular Association. Science. https://doi.org/10.1126/science.2047859
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
