The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Complementation of the Mitotic Activator, p80 cdc25 , by a Human Protein-tyrosine Phosphatase
Abstract
The onset of M phase requires the activation of the pp34 protein kinase in all eukaryotes thus far examined. In Schizosaccharomyces pombe , pp34 is phosphorylated on Tyr 15 , and dephosphorylation of this residue regulates the initiation of mitosis. In this study, it is shown that dephosphorylation of Tyr 15 triggered activation of the pp34-cyclin complex from fission yeast, that a human protein-tyrosine phosphatase can catalyze this event both in vitro and in vivo, and that activation of fission yeast pp34 does not require threonine dephosphorylation. The complementary DNA that encoded the tyrosine phosphatase replaced the mitotic activator p80 cdc25 , closely associating the cdc25 + -activating pathway with tyrosine dephosphorylation of pp34.
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Citations
Cites
[56] Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
Moreno, S., Klar, A., & Nurse, P. (1991) · Methods in Enzymology · doi:10.1016/0076-6879(91)94059-l · Cited by 3,620
Self-citation
Cited by
Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes
Fischer, E. H., Charbonneau, H., & Tonks, N. K. (1991) · Science · doi:10.1126/science.1650499 · Cited by 956
Self-citationThe cdc25 protein contains an intrinsic phosphatase activity
Dunphy, W. G., & Kumagai, A. (1991) · Cell · doi:10.1016/0092-8674(91)90582-j · Cited by 586
Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle.
Watanabe, N., Broome, M., & Hunter, T. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07180.x · Cited by 450
A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase.
Goldbeter, A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9107 · Cited by 406
Ferrell, J. E., Wu, M., Gerhart, J. C., & Martin, G. S. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.4.1965 · Cited by 346
Metadata
- Authors
- Gould, K. L., Moreno, S., Tonks, N. K., & Nurse, P.
- Venue
- Science
- Published
- 1990-12-14
- Volume
- 250
- Issue
- 4987
- Pages
- 1573-1576
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023602283
- Cited by
- 171
- References
- 1
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gould, K. L., Moreno, S., Tonks, N. K., & Nurse, P. (1990). Complementation of the Mitotic Activator, p80 cdc25 , by a Human Protein-tyrosine Phosphatase. Science. https://doi.org/10.1126/science.1703321
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
