The DOI matches its Crossref record.
Vitamin D: A Cholecalciferol Metabolite Highly Active in Promoting Intestinal Calcium Transport
Abstract
A major polar metabolite of cholecalciferol (vitamin D 3 ) obtained from chick intestines is over four times as effective as cholecalciferol and over two times as effective as 25-hydroxycholecalciferol in stimulating intestinal calcium transport 24 hours after administration. Following a considerable lag, cholecalciferol and its 25-hydroxy derivative produce a maximum stimulation of the transport response at 24 to 48 hours. The polar intestinal metabolite greatly shortens this lag, stimulating maximum calcium transport by 9 hours. At 9 hours this metabolite is at least 13 times as active as the parent cholecalciferol and as such is a likely candidate for the biologically active form of cholecalciferol in the intestine.
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Citations
Cited by
Norman, A. W. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.491s · Cited by 1,090
Self-citationRegulation of 25-Hydroxycholecalciferol-1-Hydroxylase Activity in Kidney by Parathyroid Hormone
FRASER, D. R., & KODICEK, E. (1973) · Nature New Biology · doi:10.1038/newbio241163a0 · Cited by 527
Eisman, J. A., Hamstra, A. J., Kream, B. E., & DeLuca, H. F. (1976) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(76)90161-2 · Cited by 512
Boyle, I. T., Gray, R. W., & Deluca, H. F. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2131 · Cited by 444
Fraser, D., Kooh, S. W., Kind, H. P., Holick, M. F., Tanaka, Y., & DeLuca, H. F. (1973) · New England Journal of Medicine · doi:10.1056/nejm197310182891601 · Cited by 426
Metadata
- Authors
- Myrtle, J. F., & Norman, A. W.
- Venue
- Science
- Published
- 1971-01-08
- Volume
- 171
- Issue
- 3966
- Pages
- 79-82
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972742800
- Cited by
- 210
- References
- 0
- FWCI
- 49.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Myrtle, J. F., & Norman, A. W. (1971). Vitamin D: A Cholecalciferol Metabolite Highly Active in Promoting Intestinal Calcium Transport. Science. https://doi.org/10.1126/science.171.3966.79
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
