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Reexamination of the Folding of BPTI: Predominance of Native Intermediates
Abstract
Bovine pancreatic trypsin inhibitor (BPTI) continues to be the only protein for which a detailed pathway of folding has been described. Previous studies led to the conclusion that nonnative states are well populated in the oxidative folding of BPTI. This conclusion has broadly influenced efforts to understand protein folding. The population of intermediates present during the folding of BPTI has been reexamined by modern separation techniques. It was found that all well-populated folding intermediates contain only native disulfide bonds. These data emphasize the importance of native protein structure for understanding protein folding.
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Cited by
From Levinthal to pathways to funnels
Dill, K. A., & Chan, H. S. (1997) · Nature Structural & Molecular Biology · doi:10.1038/nsb0197-10 · Cited by 2,293
Principles of protein folding — A perspective from simple exact models
Dill, K. A., Bromberg, S., Yue, K., Chan, H. S., Fiebig, K. M., Yee, D. P., & Thomas, P. D. (1995) · Protein Science · doi:10.1002/pro.5560040401 · Cited by 1,525
The folding of hen lysozyme involves partially structured intermediates and multiple pathways
Radford, S. E., Dobson, C. M., & Evans, P. A. (1992) · Nature · doi:10.1038/358302a0 · Cited by 708
Protein folding in the landscape perspective: Chevron plots and non-arrhenius kinetics
Chan, H. S., & Dill, K. A. (1998) · Proteins: Structure, Function, and Genetics · doi:10.1002/(sici)1097-0134(19980101)30:1<2::aid-prot2>3.0.co;2-r · Cited by 438
Ferreiro, D. U., Komives, E. A., & Wolynes, P. G. (2014) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583514000092 · Cited by 314
Metadata
- Authors
- Weissman, J. S., & Kim, P. S.
- Venue
- Science
- Published
- 1991-09-20
- Volume
- 253
- Issue
- 5026
- Pages
- 1386-1393
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073084525
- Cited by
- 512
- References
- 0
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
