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Amyloid Fibril Proteins: Proof of Homology with Immunoglobulin Light Chains by Sequence Analyses
Abstract
The sequences of the 35 and 36 amino-terminal amino acids of two purified amyloid fibril proteins have been determined. Results indicate that these two proteins are derived from homogeneous immunoglobulin light chains of variable region subgroup V κI . The relation between amyloidosis and immunoglobulins is thus more firmly established.
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Citations
Cited by
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
Self-citationProtein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
Chiti, F., & Dobson, C. M. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061516-045115 · Cited by 2,629
Molecular Mechanisms of Amyloidosis
Merlini, G., & Bellotti, V. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023144 · Cited by 1,920
Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91209-9 · Cited by 1,693
Self-citationIslet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
Westermark, P., Andersson, A., & Westermark, G. T. (2011) · Physiological Reviews · doi:10.1152/physrev.00042.2009 · Cited by 1,044
Metadata
- Authors
- Glenner, G. G., Terry, W., Harada, M., Isersky, C., & Page, D.
- Venue
- Science
- Published
- 1971-06-11
- Volume
- 172
- Issue
- 3988
- Pages
- 1150-1151
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2018593517
- Cited by
- 590
- References
- 0
- FWCI
- 16.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Glenner, G. G., Terry, W., Harada, M., Isersky, C., & Page, D. (1971). Amyloid Fibril Proteins: Proof of Homology with Immunoglobulin Light Chains by Sequence Analyses. Science. https://doi.org/10.1126/science.172.3988.1150
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.