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Refined Structure of Charybdotoxin: Common Motifs in Scorpion Toxins and Insect Defensins
Abstract
Conflicting three-dimensional structures of charybdotoxin (Chtx), a blocker of K+channels, have been previously reported. A high-resolution model depicting the tertiary structure of Chtx has been obtained by DIANA and X-PLOR calculations from new proton nuclear magnetic resonance (NMR) data. The protein possesses a small triple-stranded antiparallel β sheet linked to a short helix by two disulfides and to an extended fragment by one disulfide, respectively. This motif also exists in all known structures of scorpion toxins, irrespective of their size, sequence, and function. Strikingly, antibacterial insect defensins also adopt this folding pattern.
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Cited by
Neuronal Nicotinic Acetylcholine Receptors as Targets for Drug Discovery
Holladay, M. W., Dart, M. J., & Lynch, J. K. (1997) · Journal of Medicinal Chemistry · doi:10.1021/jm970377o · Cited by 444
Spatial Localization of the K+ Channel Selectivity Filter by Mutant Cycle–Based Structure Analysis
Ranganathan, R., Lewis, J. H., & MacKinnon, R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80030-6 · Cited by 295
Molecular Determinants of BK Channel Functional Diversity and Functioning
Latorre, R., Castillo, K., Carrasquel-Ursulaez, W., Sepulveda, R. V., Gonzalez-Nilo, F., Gonzalez, C., & Alvarez, O. (2017) · Physiological Reviews · doi:10.1152/physrev.00001.2016 · Cited by 271
An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula
Swartz, K. J., & MacKinnon, R. (1995) · Neuron · doi:10.1016/0896-6273(95)90184-1 · Cited by 261
Andrés, M. T., Yount, N. Y., Acosta-Zaldívar, M., Yeaman, M. R., & Fierro, J. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179672 · Cited by 5
Metadata
- Authors
- Bontems, F., Roumestand, C., Gilquin, B., Ménez, A., & Toma, F.
- Venue
- Science
- Published
- 1991-12-06
- Volume
- 254
- Issue
- 5037
- Pages
- 1521-1523
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965952074
- Cited by
- 365
- References
- 0
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bontems, F., Roumestand, C., Gilquin, B., Ménez, A., & Toma, F. (1991). Refined Structure of Charybdotoxin: Common Motifs in Scorpion Toxins and Insect Defensins. Science. https://doi.org/10.1126/science.1720574
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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