Gonadotropin-releasing hormone: One polypeptide regulates secretion of luteinizing and follicle-stimulating hormones
Abstract
A polypeptide isolated from porcine hypothalami stimulates the release of both luteinizing hormone and follicle-stimulating hormone from the pituitaries of several species. This polypeptide has been structurally identified as (pyro)Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH(2) and synthesized. The natural and synthetic materials share biological properties. It appears that this peptide represents the hypothalamic hormone regulating the secretion of both luteinizing hormone and follicle-stimulating hormone.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This occurs via enhanced release of 2 glycoprotein hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the anterior pituitary, promoting steroidogenesis and the maturation of gametes.
“This occurs via enhanced release of 2 glycoprotein hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), from the anterior pituitary (15), promoting steroidogenesis and the maturation of gametes (16).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [16]
Cites
Structure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence
Matsuo, H., Baba, Y., Nair, R. M. G., Arimura, A., & Schally, A. V. (1971) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(71)80019-0 · Cited by 1,194 · see citing works
Self-citationStructure of the porcine LH- and FSH-releasing hormone. I. The proposed amino acid sequence
(1976) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(76)90821-8 · Cited by 1,033 · see citing works
Radioimmunoassay: A Method for Human Chorionic Gonadotropin and Human Luteinizing Hormone1
MIDGLEY, A. R. (1966) · Endocrinology · doi:10.1210/endo-79-1-10 · Cited by 760 · see citing works
STEELMAN, S. L., & Pohley, F. M. (1953) · Endocrinology · doi:10.1210/endo-53-6-604 · Cited by 698 · see citing works
Isolation and properties of the FSH and LH-releasing hormone
Schally, A. V., Arimura, A., Baba, Y., Nair, R. M. G., Matsuo, H., Redding, T. W., Debéljuk, L., & White, W. F. (1971) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(71)90766-2 · Cited by 664 · see citing works
Self-citationBaba, Y., Matsuo, H., & Schally, A. V. (1971) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(71)90623-1 · Cited by 247 · see citing works
Self-citationHypothalamic Neurohormones Regulating Anterior Pituitary Function
Schally, A. V., Arimura, A., BOWERS, C. Y., et al. (1968) · Elsevier eBooks · doi:10.1016/b978-1-4831-9827-9.50016-2 · Cited by 163 · see citing works
Self-citationTHE NEUROENDOCRINE REGULATION OF HYPOPHYSEAL LUTEINIZING HORMONE SECRETION.
McCann, S. M., & Vd, R. (1964) · PubMed · Cited by 94 · see citing works
THE HYPOTHALAMUS AND CONTROL OF OVULATION
Harris, G. W., & Naftolin, F. N. (1970) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a070739 · Cited by 86 · see citing works
Stimulation of LH Release in Men and Women by LH-Releasing Hormone Purified from Porcine Hypothalami
Kastin, A. J., Schally, A. V., Gual, C. G., et al. (1969) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-29-8-1046 · Cited by 77 · see citing works
Self-citationEvidence for peptide nature of LH and FSH-releasing hormones
Schally, A. V., Baba, Y., Arimura, A., et al. (1971) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(71)90360-3 · Cited by 63 · see citing works
Self-citationProgesterone Blockade of the Ovulatory Response to Intrapituitary Infusion of LH-RH in Rabbits
Hilliard, J., Schally, A. V., & Sawyer, C. H. (1971) · Endocrinology · doi:10.1210/endo-88-3-730 · Cited by 59 · see citing works
Self-citationAdministration of LH-releasing hormone to selected subjects
Kastin, A. J., Schally, A. V., Gual, C. G., et al. (1970) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(70)90293-0 · Cited by 56 · see citing works
Self-citationEffects of Hypothalamic Extract and Androgen on Pituitary FSH Releasein Vitro
MITTLER, J. C., & Meites, J. (1966) · Endocrinology · doi:10.1210/endo-78-3-500 · Cited by 53 · see citing works
Purification of Hypothalamic Releasing Hormones of Human Origin1
Schally, A. V., Arimura, A., Bowers, C. Y., et al. (1970) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-31-3-291 · Cited by 39 · see citing works
Self-citationMITTLER, J. C., Arimura, A., & Schally, A. V. (1970) · Experimental Biology and Medicine · doi:10.3181/00379727-133-34681 · Cited by 33 · see citing works
Self-citationFailure of Putrescine and Other Polyamines To Promote FSH Releasein Vitro
Schally, A. V., MITTLER, J. C., & White, W. F. (1970) · Endocrinology · doi:10.1210/endo-86-4-903 · Cited by 25 · see citing works
Self-citationStudies on Dose Response Relationship of Luteinizing Hormone-Releasing Hormone (Lh-Rh) in Sheep
Reeves, J. J., Arimura, A., & Schally, A. V. (1970) · Journal of Animal Science · doi:10.2527/jas1970.315933x · Cited by 24 · see citing works
Self-citationSchally, A. V., Baba, Y., & Redding, T. W. (2008) · Neuroendocrinology · doi:10.1159/000121994 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Lehman, M. N., Coolen, L. M., & Goodman, R. L. (2010) · Endocrinology · doi:10.1210/en.2010-0022 · Cited by 768 · see citing works
Schwanzel-Fukuda, M., Bick, D., & Pfaff, D. W. (1989) · Molecular Brain Research · doi:10.1016/0169-328x(89)90076-4 · Cited by 616 · see citing works
Gonadal steroid hormones and the hypothalamo–pituitary–adrenal axis
Handa, R. J., & Weiser, M. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.001 · Cited by 408 · see citing works
Testosterone and Depression: Systematic Review and Meta-Analysis
Zarrouf, F. A., Artz, S., Griffith, J., Sirbu, C., & Kommor, M. (2009) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000358315.88931.fc · Cited by 383 · see citing works
Raga, F., Casañ, E. M., Kruessel, J. S., Wen, Y., Huang, H.-Y., Nezhat, C., & Polan, M. L. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.3.661 · Cited by 158 · see citing works
Ng, J., Chwalisz, K., Carter, D. C., & Klein, C. E. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-3845 · Cited by 110 · see citing works
The evolution and nomenclature of GnRH-type and corazonin-type neuropeptide signaling systems
Zandawala, M., Tian, S., & Elphick, M. R. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.06.007 · Cited by 105 · see citing works
LHRH-targeted nanogels as a delivery system for cisplatin to ovarian cancer
Nukolova, N. V., Oberoi, H. S., Zhao, Y., Chekhonin, V. P., Kabanov, A. V., & Bronich, T. K. (2013) · Molecular Pharmaceutics · doi:10.1021/mp4003688 · Cited by 63 · see citing works
Andreatta, G., Broyart, C., Borghgraef, C., Vadiwala, K., Kozin, V., Polo, A., Bileck, A., Beets, I., Schoofs, L., Gerner, C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1910262116 · Cited by 61 · see citing works
Ullah, R., Shen, Y., Zhou, Y.-D., Huang, K., Fu, J.-F., Wahab, F., & Shahab, M. (2016) · Neuropeptides · doi:10.1016/j.npep.2016.05.004 · Cited by 30 · see citing works
- Authors
- Schally, A. V., Arimura, A., Kastin, A. J., Matsuo, H., Baba, Y., Redding, T. W., Nair, R. M. G., Debeljuk, L., & White, W. F.
- Affiliations
- Veterans Administration Hospital and Tulanie University School of Medicine, New Orleans, Louisiana 70140
- Abbott (United States) (US)
- Venue
- Science
- Published
- 1971-09-10
- Volume
- 173
- Issue
- 4001
- Pages
- 1036-1038
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2018739526
- Cited by
- 770
- References
- 19
- Citations by year
- 2026: 14 · 2025: 9 · 2024: 22 · 2023: 34 · 2022: 13 · 2021: 24 · 2020: 22 · 2019: 30 · 2018: 26 · 2017: 20 · 2016: 14 · 2015: 9 · 2014: 20 · 2013: 25 · 2012: 17
- FWCI
- 44.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- gonadotropin-releasing hormone, luteinizing hormone, follicle-stimulating hormone, hypothalamic hormones, pituitary hormone secretion, peptide structure, synthetic peptides, gonadotropin regulation
- MeSH terms
- Amino Acid Sequence, Animals, Contraceptives, Oral, Follicle Stimulating Hormone, Hypothalamus, Luteinizing Hormone, Male, Peptides, Pituitary Gland, Pituitary Hormone-Releasing Hormones, Swine, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
