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Proportional Release of Norepinephrine and Dopamine-β-Hydroxylase from Sympathetic Nerves
Abstract
Dopamine-β-hydroxylase (DBH), the enzyme that catalyzes the conversion of dopamine to norepinephrine, is localized in the vesicles containing catecholamine in sympathetic nerves. This enzyme is released with norepinephrine when the nerves to the guinea pig vas deferens are stimulated in vitro, and the amount of enzyme discharged increases as the length of stimulation periods increases. The amount of DBH released is proportional to the amount of norepinephrine released, and the ratio of norepinephrine to DBH discharged into the incubation medium is similar to that in the soluble portion of the contents of the synaptic vesicles from the vas deferens. These data are compatible with the release of the neurotransmitter norepinephrine and DBH from sympathetic nerves by a process of exocytosis.
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Cited by
Dopamine: Functions, Signaling, and Association with Neurological Diseases
Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0632-3 · Cited by 1,073
The Sympathetic-Nervous-System Defect in Primary Orthostatic Hypotension
Ziegler, M. G., Lake, C. R., & Kopin, I. J. (1977) · New England Journal of Medicine · doi:10.1056/nejm197702102960601 · Cited by 355
Self-citationAlexander, R. W., Gill, J. R., Yamabe, H., Lovenberg, W., & Keiser, H. R. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107743 · Cited by 276
The role of noradrenaline in the generation of the preovulatory LH surge in the ewe
Clarke, I. J., Scott, C. J., Pereira, A., & Pompolo, S. (2006) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2005.07.006 · Cited by 22
Metadata
- Authors
- Weinshilboum, R. M., Thoa, N. B., Johnson, D. G., Kopin, I. J., & Axelrod, J.
- Venue
- Science
- Published
- 1971-12-24
- Volume
- 174
- Issue
- 4016
- Pages
- 1349-1351
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969792498
- Cited by
- 322
- References
- 0
- FWCI
- 11.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weinshilboum, R. M., Thoa, N. B., Johnson, D. G., Kopin, I. J., & Axelrod, J. (1971). Proportional Release of Norepinephrine and Dopamine-β-Hydroxylase from Sympathetic Nerves. Science. https://doi.org/10.1126/science.174.4016.1349
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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