Cited by 1,073Neurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

Dopamine: Functions, Signaling, and Association with Neurological Diseases

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Klein, Marianne O., Battagello, Daniella S., Cardoso, Ariel R., Hauser, David N., Bittencourt, Jackson C., Correa, Ricardo G.·2019·Cellular and Molecular Neurobiology

Abstract

The dopaminergic system plays important roles in neuromodulation, such as motor control, motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a neurotransmitter, synthesized in both central nervous system and the periphery, that exerts its actions upon binding to G protein-coupled receptors. Dopamine receptors are widely expressed in the body and function in both the peripheral and the central nervous systems. Dopaminergic signaling pathways are crucial to the maintenance of physiological processes and an unbalanced activity may lead to dysfunctions that are related to neurodegenerative diseases. Unveiling the neurobiology and the molecular mechanisms that underlie these illnesses may contribute to the development of new therapies that could promote a better quality of life for patients worldwide. In this review, we summarize the aspects of dopamine as a catecholaminergic neurotransmitter and discuss dopamine signaling pathways elicited through dopamine receptor activation in normal brain function. Furthermore, we describe the potential involvement of these signaling pathways in evoking the onset and progression of some diseases in the nervous system, such as Parkinson's, Schizophrenia, Huntington's, Attention Deficit and Hyperactivity Disorder, and Addiction. A brief description of new dopaminergic drugs recently approved and under development treatments for these ailments is also provided.

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Crossref · 10.1007/s10571-018-0632-3

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Authors
Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G.
Affiliations
  • Universidade de São Paulo (BR)
  • Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author
  • Bittencourt, Jackson C.
  • Correa, Ricardo G.
Venue
Cellular and Molecular Neurobiology
Published
2018-11-16
Volume
39
Issue
1
Pages
31-59
ISSN
  • 0272-4340 (ISSN-L)
  • 1573-6830
OpenAlex
W2901208536
Cited by
1,073
References
472
Citations by year
2026: 141 · 2025: 174 · 2024: 214 · 2023: 199 · 2022: 148 · 2021: 105 · 2020: 64 · 2019: 27 · 2012: 1
FWCI
6.41
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Neurobiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
dopamine, dopaminergic signaling, dopamine receptors, G protein-coupled receptors, catecholamine neurotransmitters, neuromodulation, neurodegenerative diseases, Parkinson's disease, schizophrenia, Huntington's disease, attention deficit hyperactivity disorder, addiction, dopaminergic therapy, reward and motivation
MeSH terms
Animals, Brain, Dopamine, Humans, Models, Biological, Nervous System Diseases, Signal Transduction

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