The DOI matches its Crossref record.
1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture
Abstract
1,25-Dihydroxycholecalciferol (DHCC), isolated from kidney homogenates incubated with 25-hydroxycholecalciferol (HCC), stimulated the release of previously incorporated 45 Ca from fetal rat bones in organ culture, at concentrations of 10 -10 to 10 -8 M . The dose response curves for 1,25-DHCC and 25-HCC, the parent compound, are parallel, but 1,25-DHCC is about 100 times as potent on a weight basis. Brief exposure to maximum doses of either agent leads to prolonged bone resorption.
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Citations
Cited by
Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.
Abe, E., Miyaura, C., Sakagami, H., Takeda, M., Konno, K., Yamazaki, T., Yoshiki, S., & Suda, T. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.8.4990 · Cited by 1,020
Fraser, D., Kooh, S. W., Kind, H. P., Holick, M. F., Tanaka, Y., & DeLuca, H. F. (1973) · New England Journal of Medicine · doi:10.1056/nejm197310182891601 · Cited by 426
Self-citationWoodson, G. C. (1998) · Bone · doi:10.1016/s8756-3282(98)00060-x · Cited by 104
Metadata
- Authors
- Raisz, L. G., Trummel, C. L., Holick, M. F., & Deluca, H. F.
- Venue
- Science
- Published
- 1972-02-18
- Volume
- 175
- Issue
- 4023
- Pages
- 768-769
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969429995
- Cited by
- 628
- References
- 0
- FWCI
- 14.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: 1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture. https://app.cochat.ai/papers/10.1126/science.175.4023.768
- The paper
- Raisz, L. G., Trummel, C. L., Holick, M. F., & Deluca, H. F. (1972). 1,25-Dihydroxycholecalciferol: A Potent Stimulator of Bone Resorption in Tissue Culture. Science. https://doi.org/10.1126/science.175.4023.768
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
