The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.
Open accessAbstract
Mouse myeloid leukemia cells can be induced to differentiate into macrophages in vitro by 1 alpha,25-dihydroxyvitamin D3, the active form of vitamin D3. The minimal concentration of 1 alpha,25-dihydroxyvitamin D3 to induce the cell differentiation was 0.12 nM. The degree of cell differentiation in various markers induced by 12 nM 1 alpha,25-dihydroxyvitamin D3 was nearly equivalent to that induced by 1 microM dexamethasone, the most potent known stimulator. Among several markers of the differentiation by 1 alpha,25-dihydroxyvitamin D3, phagocytic activity was induced within 24 hr, and this was followed by induction of lysozyme and locomotive activities. Similar changes were also induced by 0.01-1 microM 1 alpha-hydroxyvitamin D3. 25-Hydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3 showed only weak inducing activity. These results suggest the possibility that, in addition to its wellknown biological activities in enhancing intestinal calcium transport and bone mineral mobilization, 1 alpha, 25-dihydroxyvitamin D3 is involved in the differentiation of bone marrow cells.
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Self-citationThe physiological and cellular basis of metabolic bone disease
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Cited by
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
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The role of vitamin D in reducing cancer risk and progression
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Self-citationNew clues about vitamin D functions in the nervous system
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Expression of 1,25-Dihydroxyvitamin D3 Receptor in the Immune System
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Metadata
- Authors
- Abe, E., Miyaura, C., Sakagami, H., Takeda, M., Konno, K., Yamazaki, T., Yoshiki, S., & Suda, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-08
- Volume
- 78
- Issue
- 8
- Pages
- 4990-4994
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2036088433
- Cited by
- 1,020
- References
- 10
- FWCI
- 21.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Abe, E., Miyaura, C., Sakagami, H., Takeda, M., Konno, K., Yamazaki, T., Yoshiki, S., & Suda, T. (1981). Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.78.8.4990
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