The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Immune Reaction as a Stimulator of Tumor Growth
Abstract
Various numbers of spleen cells from specifically immunized mice were mixed with constant numbers of target tumor cells, and were inoculated subcutaneously into thymectomized, x-irradiated recipients. Small numbers of admixed immune spleen cells produced a statistically significant, and reproducible, acceleration of tumor growth in the inoculum as compared with controls of either nonimmune spleen cells or spleen cells from animals immune to a different, noncross-reacting, tumor. Larger numbers of specifically immune spleen cells, however, produced inhibition of tumor growth. These data imply that the normal immune reaction may have a dual function in relation to neoplasia: (i) stimulation of tumor growth, early in the course of the disease, or whenever the immune reaction is minimal; (ii) inhibition of tumor growth at other times.
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Cites
Perspectives on oncogenesis: does immunity stimulate or inhibit neoplasia?
Rt, P. (1971) · PubMed · Cited by 72
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The Biology of Cancer Invasion and Metastasis
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Cytokines and their relationship to the symptoms and outcome of cancer
Seruga, B., Zhang, H., Bernstein, L. J., & Tannock, I. F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2507 · Cited by 652
Nicolson, G. L. (1982) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(82)90020-8 · Cited by 560
Nicolson, G. L. (1988) · CANCER AND METASTASIS REVIEW · doi:10.1007/bf00046483 · Cited by 502
Metadata
- Authors
- Prehn, R. T.
- Venue
- Science
- Published
- 1972-04-14
- Volume
- 176
- Issue
- 4031
- Pages
- 170-171
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968746678
- Cited by
- 397
- References
- 1
- FWCI
- 12.25
- Type
- journal article
- Language
- en
- Open access
- closed
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