Cited by 652Nutrition and Health in AgingTryptophan and brain disordersInflammatory Biomarkers in Disease Prognosis

Cytokines and their relationship to the symptoms and outcome of cancer

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Seruga, Bostjan, Zhang, Haibo, Bernstein, Lori J., Tannock, Ian F.·2008·Nature Reviews Cancer

Abstract

Tumours contain immune cells and a network of pro- and anti-inflammatory cytokines, which collaborate in the development and progression of cancer. Cytokine profiles might prove to be prognostic. The systemic effects of pro-inflammatory cytokines are associated with fatigue, depression and cognitive impairment, and can affect quality of life before, during and after treatment. In people with advanced cancer, pro-inflammatory cytokines are additionally associated with anorexia and cachexia, pain, toxicity of treatment and resistance to treatment. However, physical activity might modify cytokine levels and decrease fatigue in patients with cancer, and might also improve their prognosis.

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  • Treatment of physical disorders, including interferon-based or virostatic treatments for hepatitis C, chemotherapy for cancer, surgery, or transplantation, can lead to additional cytokine release.

    “The treatment of physical disorders, e.g., interferon-based or virostatic treatments for hepatitis C (167, 197), chemotherapy for the treatment of cancer (168), surgery (169) or transplantation (170), can lead to additional cytokine release.”

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Authors
Seruga, B., Zhang, H., Bernstein, L. J., & Tannock, I. F.
Affiliations
St. Michael's Hospital (CA)
Corresponding author
Tannock, Ian F.
Venue
Nature Reviews Cancer
Published
2008-10-10
Volume
8
Issue
11
Pages
887-899
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2061366514
Cited by
652
References
250
Citations by year
2026: 11 · 2025: 23 · 2024: 35 · 2023: 26 · 2022: 37 · 2021: 47 · 2020: 33 · 2019: 33 · 2018: 45 · 2017: 33 · 2016: 48 · 2015: 41 · 2014: 45 · 2013: 45 · 2012: 60
FWCI
3.26
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • TSpace (University of Toronto) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
inflammatory cytokines, advanced cancer, cancer-related fatigue, cancer cachexia, anorexia, cancer pain, depression, cognitive impairment, treatment toxicity, treatment resistance, tumor immune microenvironment, quality of life, physical activity, cytokine signaling pathways
MeSH terms
Anorexia, Cachexia, Depressive Disorder, Humans, Neoplasms, Cytokines

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