The DOI matches its Crossref record.
Broad-Spectrum Antiviral Activity of Virazole: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
Abstract
Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses. Applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice. Injected intraperitoneally into mice, it inhibits splenomegaly and hepatomegaly induced by Friend leukemia virus and respiratory infections caused by influenza A 0 , A 2 , and B viruses and parainfluenza 1 virus. Oral or aerosol treatment of parainfluenza virus infections is also effective.
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Citations
Cited by
Antiviral agents active against influenza A viruses
De Clercq, E. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2175 · Cited by 668
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Parce, J. W., Owicki, J. C., Kercso, K. M., Sigal, G. B., Wada, H. G., Muir, V. C., Bousse, L. J., Ross, K. L., Sikic, B. I., & McConnell, H. M. (1989) · Science · doi:10.1126/science.2799384 · Cited by 295
Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies
Gowen, B. B., & Hickerson, B. T. (2017) · Journal of Microbiology · doi:10.1007/s12275-017-7029-8 · Cited by 26
Metadata
- Authors
- Sidwell, R. W., Huffman, J. H., Khare, L., Allen, B., Witkowski, R., & Robins, K.
- Venue
- Science
- Published
- 1972-08-25
- Volume
- 177
- Issue
- 4050
- Pages
- 705-706
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012051375
- Cited by
- 985
- References
- 0
- FWCI
- 14.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Broad-Spectrum Antiviral Activity of Virazole: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide. https://app.cochat.ai/papers/10.1126/science.177.4050.705
- The paper
- Sidwell, R. W., Huffman, J. H., Khare, L., Allen, B., Witkowski, R., & Robins, K. (1972). Broad-Spectrum Antiviral Activity of Virazole: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide. Science. https://doi.org/10.1126/science.177.4050.705
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
