The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Detection of Cell-Affecting Agents with a Silicon Biosensor
Abstract
Cellular metabolism is affected by many factors in a cell's environment. Given a sufficiently sensitive method for measuring cellular metabolic rates, it should be possible to detect a wide variety of chemical and physical stimuli. A biosensor has been constructed in which living cells are confined to a flow chamber in which a potentiometric sensor continually measures the rate of production of acidic metabolites. Exploratory studies demonstrate several applications of the device in basic science and technology.
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Cites
DRAIZE, J. H., WOODARD, G., & CALVERY, H. O. (1944) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)08751-8 · Cited by 2,602
Biosensors: fundamentals and applications
Turner, A. P. F., Karube, I., Wilson, G. S., & Worsfold, P. J. (1987) · Analytica Chimica Acta · doi:10.1016/s0003-2670(00)85361-1 · Cited by 1,320
Broad-Spectrum Antiviral Activity of Virazole: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
Sidwell, R. W., Huffman, J. H., Khare, L., Allen, B., Witkowski, R., & Robins, K. (1972) · Science · doi:10.1126/science.177.4050.705 · Cited by 985
Light-Addressable Potentiometric Sensor for Biochemical Systems
Hafeman, D. G., Parce, J. W., & McConnell, H. M. (1988) · Science · doi:10.1126/science.3375810 · Cited by 709
Self-citationA piezoelectric micropump based on micromachining of silicon
van Lintel, H. T. G., van De Pol, F. C. M., & Bouwstra, S. (1988) · Sensors and Actuators · doi:10.1016/0250-6874(88)87005-7 · Cited by 620
Mechanism of multidrug resistance
Bradley, G., Juranka, P. F., & Ling, V. (1988) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(88)90006-6 · Cited by 617
Controlled outgrowth of dissociated neurons on patterned substrates
Kleinfeld, D., Kahler, K., & Hockberger, P. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-11-04098.1988 · Cited by 569
Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues
Hue, L., & Rider, M. H. (1987) · Biochemical Journal · doi:10.1042/bj2450313 · Cited by 422
Boyce, S. T., & Ham, R. G. (1985) · Journal of Tissue Culture Methods · doi:10.1007/bf01797779 · Cited by 263
Ion-sensing devices with silicon nitride and borosilicate glass insulators
Harame, D. L., Bousse, L. J., Shott, J. D., & Meindl, J. D. (1987) · IEEE Transactions on Electron Devices · doi:10.1109/t-ed.1987.23140 · Cited by 225
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Cited by
Revealing neuronal function through microelectrode array recordings
Obien, M. E. J., Deligkaris, K., Bullmann, T., Bakkum, D. J., & Frey, U. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00423 · Cited by 705
Comparison of the hysteresis of Ta2O5 and Si3N4 pH-sensing insulators
Bousse, L., Mostarshed, S., van der Schoot, B., & de Rooij, N. F. (1994) · Sensors and Actuators B: Chemical · doi:10.1016/0925-4005(94)87044-6 · Cited by 177
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Metadata
- Authors
- Parce, J. W., Owicki, J. C., Kercso, K. M., Sigal, G. B., Wada, H. G., Muir, V. C., Bousse, L. J., Ross, K. L., Sikic, B. I., & McConnell, H. M.
- Venue
- Science
- Published
- 1989-10-13
- Volume
- 246
- Issue
- 4927
- Pages
- 243-247
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023123970
- Cited by
- 295
- References
- 16
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Detection of Cell-Affecting Agents with a Silicon Biosensor. https://app.cochat.ai/papers/10.1126/science.2799384
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- Parce, J. W., Owicki, J. C., Kercso, K. M., Sigal, G. B., Wada, H. G., Muir, V. C., Bousse, L. J., Ross, K. L., Sikic, B. I., & McConnell, H. M. (1989). Detection of Cell-Affecting Agents with a Silicon Biosensor. Science. https://doi.org/10.1126/science.2799384
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
