Cited by 296Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorHypothalamic control of reproductive hormones

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Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats

Zigmond, Michael J., Stricker, Edward M.·1972·Science

DOI 10.1126/science.177.4055.1211

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Abstract

Intraventricular injections of 6-hydroxydopamine produced 95 percent depletion of telencephalic norepinephrine and 62 percent depletion of striatal dopamine in rats. Treated rats maintained body weight at subnormal levels and failed to increase food intake in response to a short-term decrease in glucose utilization. After treatment with the monoamine oxidase inhibitor pargyline, 6-hydroxydopamine produced no further norepinephrine depletion but increased the dopamine depletion to 95 percent and produced complete aphagia. These effects are comparable to events that follow bilateral electrolytic lesions of the lateral hypothalamus.

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BIOCHEMICAL AND BEHAVIOURAL ALTERATIONS FOLLOWING 6-HYDROXYDOPAMINE ADMINISTRATION INTO BRAIN**Supported by USPHS grants MH-16522 and HD-03110. G.R.B. is a Career Development Awardee (HD-24585). B.R.C. and R.D.S. are post-doctoral fellows (MH-11107).
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Authors: Zigmond, M. J., & Stricker, E. M.
Affiliations: University of Pittsburgh (US)
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1972-09-29
Volume: 177
Issue: 4055
Pages: 1211-1214
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.177.4055.1211
OpenAlex: W2091764078
Cited by: 296
References: 31
Citations by year: 2026: 1 · 2022: 2 · 2021: 3 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 3 · 2012: 6
FWCI: 13.82
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: 6-hydroxydopamine, feeding behavior, dietary intake, norepinephrine depletion, dopamine depletion, intraventricular injection, pargyline, monoamine oxidase inhibition, aphagia, lateral hypothalamus, glucose utilization, body weight
MeSH terms: Animals, Behavior, Animal, Body Weight, Brain Chemistry, Cerebral Ventricles, Dopamine, Feeding Behavior, Hexoses, Hydroxylamines, Hypothalamus, Injections, Male, Norepinephrine, Pargyline, Telencephalon, Thalamus, Rats

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Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats

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