The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats
Abstract
Intraventricular injections of 6-hydroxydopamine produced 95 percent depletion of telencephalic norepinephrine and 62 percent depletion of striatal dopamine in rats. Treated rats maintained body weight at subnormal levels and failed to increase food intake in response to a short-term decrease in glucose utilization. After treatment with the monoamine oxidase inhibitor pargyline, 6-hydroxydopamine produced no further norepinephrine depletion but increased the dopamine depletion to 95 percent and produced complete aphagia. These effects are comparable to events that follow bilateral electrolytic lesions of the lateral hypothalamus.
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“These results suggest that DA release in the striatum is required to integrate relevant signals for sustained feeding [301,314,315].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [315]
Citations
Cites
6-Hydroxy-dopamine induced degeneration of central monoamine neurons.
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Ascending Monoamine Neurons to the Telencephalon and Diencephalon
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Hypothalamic control of food intake in rats and cats.
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Demonstration and mapping out of nigro-neostriatal dopamine neurons
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EFFECTS OF 6‐HYDROXYDOPAMINE ON CATECHOLAMINE CONTAINING NEURONES IN THE RAT BRAIN
Uretsky, N. J., & Iversen, L. L. (1970) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1970.tb02210.x · Cited by 654
6-Hydroxydopamine and catecholamine neurons
Malmfors, T., Thoenen, H., & Co, F. H.-L. R. (1971) · North-Holland eBooks · Cited by 634
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Depletion of brain noradrenaline and dopamine by 6‐hydroxydopamine
Breese, G. R., & Traylor, T. D. (1971) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1971.tb07089.x · Cited by 534
Research works printed but not linked: 6
- Epstein, A. N., Progress in Physiological Psychology: 263 (1971).
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Cited by
Sorted by citations
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants
Björklund, A., & Stenevi, U. (1979) · Brain Research · doi:10.1016/0006-8993(79)90472-4 · Cited by 830
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
Zhou, Q.-Y., & Palmiter, R. D. (1995) · Cell · doi:10.1016/0092-8674(95)90145-0 · Cited by 731
Hernandez, L., & Hoebel, B. G. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90036-7 · Cited by 627
Nigrostriatal bundle damage and the lateral hypothalamic syndrome.
Marshall, J. F., Richardson, J. S., & Teitelbaum, P. (1974) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0037223 · Cited by 625
Metadata
- Authors
- Zigmond, M. J., & Stricker, E. M.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Science
- Published
- 1972-09-29
- Volume
- 177
- Issue
- 4055
- Pages
- 1211-1214
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091764078
- Cited by
- 296
- References
- 31
- Citations by year
- 2026: 1 · 2022: 2 · 2021: 3 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 3 · 2012: 6
- FWCI
- 13.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- 6-hydroxydopamine, feeding behavior, dietary intake, norepinephrine depletion, dopamine depletion, intraventricular injection, pargyline, monoamine oxidase inhibition, aphagia, lateral hypothalamus, glucose utilization, body weight
- MeSH terms
- Animals, Behavior, Animal, Body Weight, Brain Chemistry, Cerebral Ventricles, Dopamine, Feeding Behavior, Hexoses, Hydroxylamines, Hypothalamus, Injections, Male, Norepinephrine, Pargyline, Telencephalon, Thalamus, Rats
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