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Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids
Abstract
When plasma tryptophan is elevated by the injection of tryptophan or insulin, or by the consumption of carbohydrates, brain tryptophan and serotonin also rise; however, when even larger elevations of plasma tryptophan are produced by the ingestion of protein-containing diets, brain tryptophan and serotonin do not change. The main determinant of brain tryptophan and serotonin concentrations does not appear to be plasma tryptophan alone, but the ratio of this amino acid to other plasma neutral amino acids (that is, tyrosine, phenylalanine, leucine, isoleucine, and valine) that compete with it for uptake into the brain.
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Citations
Cited by
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New insights into symptoms and neurocircuit function of anorexia nervosa
Kaye, W. H., Fudge, J. L., & Paulus, M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2682 · Cited by 843
Neuropathogenesis of Delirium: Review of Current Etiologic Theories and Common Pathways
Maldonado, J. R. (2013) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.09.005 · Cited by 745
Neurobiology of anorexia and bulimia nervosa
Kaye, W. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.037 · Cited by 625
Structure of the Blood–Brain Barrier and Its Role in the Transport of Amino Acids
Hawkins, R. A., O’Kane, R. L., Simpson, I. A., & Viña, J. R. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.1.218s · Cited by 453
Metadata
- Authors
- Fernstrom, J. D., & Wurtman, R. J.
- Venue
- Science
- Published
- 1972-10-27
- Volume
- 178
- Issue
- 4059
- Pages
- 414-416
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092299253
- Cited by
- 1,160
- References
- 0
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fernstrom, J. D., & Wurtman, R. J. (1972). Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids. Science. https://doi.org/10.1126/science.178.4059.414
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
