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Flagellar Movement: A Sliding Filament Model: An explanation is suggested for the spontaneous propagation of bending waves by flagella.
Abstract
A sliding filament mechanism appears to provide the most satisfactory basis for a simple feedback mechanism for the control of bend propagation and bend initiation by flagella, and is supported by strong experimental evidence. A computer simulation of the movements of a flagellar model based on the sliding filament mechanism demonstrates that this mechanism offers a sufficient explanation for the automatic generation of flagellar bending waves. Further computer simulation studies may provide insight into questions such as the applicability of the sliding filament mechanism to the generation of the more complicated asymmetrical bending patterns of cilia, and the control of the bending pattern by interaction between several sliding filament systems within a flagellum.
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Citations
Cited by
Lighthill, J. (1976) · SIAM Review · doi:10.1137/1018040 · Cited by 738
Flagellar and ciliary beating: the proven and the possible
Lindemann, C. B., & Lesich, K. A. (2010) · Journal of Cell Science · doi:10.1242/jcs.051326 · Cited by 291
Sperm flagella: comparative and phylogenetic perspectives of protein components
Inaba, K. (2011) · Molecular Human Reproduction · doi:10.1093/molehr/gar034 · Cited by 287
Smith, E. F., & Yang, P. (2004) · Cell Motility · doi:10.1002/cm.10155 · Cited by 279
Calcium-induced asymmetrical beating of triton-demembranated sea urchin sperm flagella.
Brokaw, C. J. (1979) · The Journal of cell biology · doi:10.1083/jcb.82.2.401 · Cited by 272
Self-citation
Metadata
- Authors
- Brokaw, C. J.
- Venue
- Science
- Published
- 1972-11-03
- Volume
- 178
- Issue
- 4060
- Pages
- 455-462
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057481524
- Cited by
- 195
- References
- 0
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Flagellar Movement: A Sliding Filament Model: An explanation is suggested for the spontaneous propagation of bending waves by flagella. https://app.cochat.ai/papers/10.1126/science.178.4060.455
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- Brokaw, C. J. (1972). Flagellar Movement: A Sliding Filament Model: An explanation is suggested for the spontaneous propagation of bending waves by flagella. Science. https://doi.org/10.1126/science.178.4060.455
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.