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Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
Abstract
A peptide has been isolated from ovine hypothalamus which, at 1 × 10 -9 M , inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH. The synthetic replicate is biologically active.
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Research works printed but not linked: 14
- BOWERS, C.Y., PORCINE THYROTROPIN RELEASING HORMONE IS (PYRO)GLU-HIS-PRO(NH2), ENDOCRINOLOGY 86: 1143 (1970). · doi:10.1210/endo-86-5-1143
- BURGUS, R, MOLECULAR STRUCTURE OF HYPOTHALAMIC HYPOPHYSIOTROPIC TRF FACTOR OF OVINE ORIGIN . MASS SPECTROMETRIC EVIDENCE OF PCA-HIS-PRO-NH2 SEQUENCE, COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE D 269: 1870 (1969).
- BURGUS, R, MOLECULAR STRUCTURE OF HYPOTHALAMIC FACTOR OF OVINE ORIGIN CONTROLLING SECRETION OF HYPOPHYSEAL GONADOTROPIC LUTEINIZING HORMONE (LH), COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE D 273: 1611 (1971).
- BURGUS, R, PRIMARY STRUCTURE OF OVINE HYPOTHALAMIC LUTEINIZING HORMONE-RELEASING FACTOR (LRF), PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 69: 278 (1972).
- DHARIWAL, APS, PURIFICATION OF A GROWTH HORMONE-INHIBITING FACTOR (GIF) FROM SHEEP HYPOTHALAMUS, NEUROENDOCRINOLOGY 4: 282 (1969). · DOI
- HOWARD, H, ENDOCRINOLOGY 88: 497 (1971). · doi:10.1210/endo-88-2-497
- KRULICH, L, STIMULATORY AND INHIBITORY EFFECTS OF PURIFIED HYPOTHALAMIC EXTRACTS ON GROWTH HORMONE RELEASE FROM RAT PITUITARY IN VITRO, ENDOCRINOLOGY 83: 783 (1968). · DOI · Paper page
- KRULICH, L, EFFECT OF GH-RELEASING FACTOR AND GH-INHIBITING FACTOR ON RELEASE AND CONCENTRATION OF GH IN PITUITARIES INCUBATED IN VITRO, ENDOCRINOLOGY 85: 319 (1969). · DOI
- KRULICH, L, GROWTH HORMONE: 32 (1968).
- LIU, T.Y., HYDROLYSIS OF PROTEINS WITH PARA-TOLUENESULFONIC ACID - DETERMINATION OF TRYPTOPHAN, JOURNAL OF BIOLOGICAL CHEMISTRY 246: 2842 (1971). · DOI · Paper page
- MATSUO, H, BIOCH BIOPHYS RES CO 43: 1344 (1971).
- RIVIER, J, SOLID-PHASE PEPTIDE SYNTHESIS ON A BENZHYDRYLAMINE RESIN OF LRF (LUTEINIZING-HORMONE RELEASING FACTOR) AND ANALOGS INCLUDING ANTAGONISTS, CHIMIA 26: 300 (1972).
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- 10.1126/science.176.4037.933 · doi:10.1126/science.176.4037.933
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Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions
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Glucagon-like peptide-1 receptor: mechanisms and advances in therapy
Zheng, Z., Zong, Y., Ma, Y., Tian, Y., Pang, Y., Zhang, C., & Gao, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01931-z · Cited by 1,036
“245,246 Hence, GLP-1 activates δ -cells and promotes somatostatin secretion, forming a multi-layered inhibitory mechanism that effectively reduces glucagon secretion.”
Background
Metadata
- Authors
- Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., & Guillemin, R.
- Venue
- Science
- Published
- 1973-01-05
- Volume
- 179
- Issue
- 4068
- Pages
- 77-79
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071310612
- Cited by
- 3,532
- References
- 0
- FWCI
- 102.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone. https://app.cochat.ai/papers/10.1126/science.179.4068.77
- The paper
- Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., & Guillemin, R. (1973). Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone. Science. https://doi.org/10.1126/science.179.4068.77
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
