The DOI matches its Crossref record.
Reduced Monoamine Oxidase Activity in Platelets: A Possible Genetic Marker for Vulnerability to Schizophrenia
Abstract
Monoamine oxidase activity in blood platelets was measured, with [ 14 C]tryptamine as substrate, in 13 monozygotic twin pairs discordant for schizophrenia and in 23 normal volunteers. The monoamine oxidase activity of both schizophrenic and nonschizophrenic co-twins was significantly lower than it was for the normals, and it was highly correlated between twins. In addition, there was a significant inverse correlation between a measure of the degree of the schizophrenic disorder and the monoamine oxidase activity. These data suggest, but do not prove, that reduced platelet monoamine oxidase activity may provide a genetic marker for vulnerability to schizophrenia.
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Cited by
Snyder, S. H., Banerjee, S. P., Yamamura, H. I., & Greenberg, D. (1974) · Science · doi:10.1126/science.184.4143.1243 · Cited by 834
Another look at the monoamine oxidases and the monoamine oxidase inhibitor drugs
Neff, N. H., & Yang, H.-Y. T. (1974) · Life Sciences · doi:10.1016/0024-3205(74)90089-7 · Cited by 324
Oreland, L., Wiberg, Å., Åsberg, M., Träskman, L., Sjöstrand, L., Thorén, P., Bertilsson, L., & Tybring, G. (1981) · Psychiatry Research · doi:10.1016/0165-1781(81)90004-4 · Cited by 273
Association between a promoter variant in the monoamine oxidase A gene and schizophrenia
Jönsson, E. G., Norton, N., Forslund, K., Mattila-Evenden, M., Rylander, G., Åsberg, M., Owen, M. J., & Sedvall, G. C. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00224-4 · Cited by 57
Metadata
- Authors
- Wyatt, R. J., Murphy, D. L., Belmaker, R., Cohen, S., Donnelly, C. H., & Pollin, W.
- Venue
- Science
- Published
- 1973-03-02
- Volume
- 179
- Issue
- 4076
- Pages
- 916-918
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002269082
- Cited by
- 304
- References
- 0
- FWCI
- 50.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wyatt, R. J., Murphy, D. L., Belmaker, R., Cohen, S., Donnelly, C. H., & Pollin, W. (1973). Reduced Monoamine Oxidase Activity in Platelets: A Possible Genetic Marker for Vulnerability to Schizophrenia. Science. https://doi.org/10.1126/science.179.4076.916
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
