Cited by 57Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorGenetic Associations and Epidemiology

Association between a promoter variant in the monoamine oxidase A gene and schizophrenia

Jönsson, Erik G., Norton, Nadine, Forslund, Kaj, Mattila-Evenden, Marja, Rylander, Gunnar, Åsberg, Marie, Owen, Michael J., Sedvall, Göran C.·2003·Schizophrenia Research

Abstract

Monoaminergic transmission has been implicated in the pathophysiology of schizophrenia. We investigated a putative functional promoter polymorphism in the monoamine oxidase A (MAOA) gene in schizophrenic patients (n=133) and control subjects (n=377). In men, there was an association between the less efficiently transcribed alleles and schizophrenia (chi(2)=4.01, df=1, p<0.05). In women, no significant differences were found. The present results support the involvement of the MAOA gene in men with schizophrenia in the investigated Swedish population but should be interpreted with caution until replicated.

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Crossref · 10.1016/s0920-9964(02)00224-4

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Authors
Jönsson, E. G., Norton, N., Forslund, K., Mattila-Evenden, M., Rylander, G., Åsberg, M., Owen, M. J., & Sedvall, G. C.
Affiliations
  • Karolinska University Hospital (SE)
  • University of Wales (GB)
Corresponding author
Jönsson, Erik G.
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2003-05
Volume
61
Issue
1
Pages
31-37
ISSN
0920-9964 (ISSN-L)
OpenAlex
W2045660257
Cited by
57
References
46
Citations by year
2026: 1 · 2022: 1 · 2021: 2 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 2
FWCI
0.51
Type
journal article
Language
en
Open access
closed
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders
  • Vetenskapsrådet
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
monoamine oxidase A, MAOA gene
MeSH terms
Adult, Alleles, Female, Finland, Genotype, Humans, Male, Middle Aged, Monoamine Oxidase, Polymorphism, Genetic, Promoter Regions, Genetic, Schizophrenia, Gene Expression

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