The DOI matches its Crossref record.
Morphine Action at Central Nervous System Sites in Rat: Analgesia or Hyperalgesia Depending on Site and Dose
Abstract
Morphine was injected via fine-gauge cannulas permanently implanted in various subcortical sites in the rat brain. In this way the blood-brain barrier was avoided and precise quantities of the drug were delivered to the intended sites. Ten micrograms of morphine in the posterior hypothalamus resulted in significant analgesia, while the same dose injected into the medial septum, the caudate, or the periaqueductal gray matter yielded hyperalgesia. The morphine-produced hyperalgesia at the last-mentioned site was accompanied by stereotyped violent circular leaps, an effect of morphine not previously reported. Thus, intracerebral injections of morphine differ significantly from systemic injections and produce either analgesia or hyperalgesia, depending on site and dose.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Functional characteristics of the midbrain periaqueductal gray.
Behbehani, M. M. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00009-k · Cited by 879
Central nervous system mechanisms of analgesia
Mayer, D. J., & Price, D. D. (1976) · Pain · doi:10.1016/0304-3959(76)90080-4 · Cited by 718
Opiate receptor: autoradiographic localization in rat brain.
Pert, C. B., Kuhar, M. J., & Snyder, S. H. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.10.3729 · Cited by 629
Opioid peptide enkephalin: immunohistochemical mapping in rat central nervous system.
Simantov, R., Kuhar, M. J., Uhl, G. R., & Snyder, S. H. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.5.2167 · Cited by 621
The role of the basal ganglia in nociception and pain
Chudler, E. H., & Dong, W. K. (1995) · Pain · doi:10.1016/0304-3959(94)00172-b · Cited by 599
Metadata
- Authors
- Jacquet, Y. F., & Lajtha, A.
- Venue
- Science
- Published
- 1973-11-02
- Volume
- 182
- Issue
- 4111
- Pages
- 490-492
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2014562627
- Cited by
- 283
- References
- 0
- FWCI
- 22.34
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Morphine Action at Central Nervous System Sites in Rat: Analgesia or Hyperalgesia Depending on Site and Dose. https://app.cochat.ai/papers/10.1126/science.182.4111.490
- The paper
- Jacquet, Y. F., & Lajtha, A. (1973). Morphine Action at Central Nervous System Sites in Rat: Analgesia or Hyperalgesia Depending on Site and Dose. Science. https://doi.org/10.1126/science.182.4111.490
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
