The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region
Abstract
The v- akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of v- akt and biochemical characterization of its product revealed that it codes for a protein kinase C-related serine-threonine kinase whose cellular homolog is expressed in most tissues, with the highest amount found in thymus. Although Akt is a serine-threonine kinase, part of its regulatory region is similar to the Src homology-2 domain, a structural motif characteristic of cytoplasmic tyrosine kinases that functions in protein-protein interactions. This suggests that Akt may form a functional link between tyrosine and serine-threonine phosphorylation pathways.
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Cited by
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Metadata
- Authors
- Bellacosa, A., Testa, J. R., Staal, S. P., & Tsichlis, P. N.
- Venue
- Science
- Published
- 1991-10-11
- Volume
- 254
- Issue
- 5029
- Pages
- 274-277
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999447199
- Cited by
- 939
- References
- 26
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bellacosa, A., Testa, J. R., Staal, S. P., & Tsichlis, P. N. (1991). A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region. Science. https://doi.org/10.1126/science.1833819
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
