The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Critical Structural Elements of the VP16 Transcriptional Activation Domain
Abstract
Virion protein 16 (VP16) of herpes simplex virus type 1 contains an acidic transcriptional activation domain. Missense mutations within this domain have provided insights into the structural elements critical for its function. Net negative charge contributed to, but was not sufficient for, transcriptional activation by VP16. A putative amphipathic alpha helix did not appear to be an important structural component of the activation domain. A phenylalanine residue at position 442 was exquisitely sensitive to mutation. Transcriptional activators of several classes contain hydrophobic amino acids arranged in patterns resembling that of VP16. Therefore, the mechanism of transcriptional activation by VP16 and other proteins may involve both ionic and specific hydrophobic interactions with target molecules.
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Citations
Cites
A novel mediator between activator proteins and the RNA polymerase II transcription apparatus
Kelleher, R. J., Flanagan, P. M., & Kornberg, R. D. (1990) · Cell · doi:10.1016/0092-8674(90)90685-8 · Cited by 450
Cited by
Synaptic Activity and the Construction of Cortical Circuits
Katz, L. C., & Shatz, C. J. (1996) · Science · doi:10.1126/science.274.5290.1133 · Cited by 3,048
Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J., & Pavletich, N. P. (1996) · Science · doi:10.1126/science.274.5289.948 · Cited by 2,206
Berger, S. L., Piña, B., Silverman, N., Marcus, G. A., Agapite, J., Regier, J. L., Triezenberg, S. J., & Guarente, L. (1992) · Cell · doi:10.1016/0092-8674(92)90100-q · Cited by 435
Self-citationBinding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.
Xiao, H., Pearson, A., Coulombe, B., Truant, R., Zhang, S., Regier, J. L., Triezenberg, S. J., Reinberg, D., Flores, O., & Ingles, C. J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.10.7013 · Cited by 361
Self-citationDurand, B., Saunders, M., Gaudon, C., Roy, B., Losson, R., & Chambon, P. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06872.x · Cited by 354
Metadata
- Authors
- Cress, W. D., & Triezenberg, S. J.
- Venue
- Science
- Published
- 1991-01-04
- Volume
- 251
- Issue
- 4989
- Pages
- 87-90
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982756681
- Cited by
- 433
- References
- 1
- FWCI
- 16.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cress, W. D., & Triezenberg, S. J. (1991). Critical Structural Elements of the VP16 Transcriptional Activation Domain. Science. https://doi.org/10.1126/science.1846049
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
