The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.
Open accessAbstract
Acidic transcriptional activation domains function well in both yeast and mammalian cells, and some have been shown to bind the general transcription factors TFIID and TFIIB. We now show that two acidic transactivators, herpes simplex virus VP16 and human p53, directly interact with the multisubunit human general transcription factor TFIIH and its Saccharomyces cerevisiae counterpart, factor b. The VP16- and p53-binding domains in these factors lie in the p62 subunit of TFIIH and in the homologous subunit, TFB1, of factor b. Point mutations in VP16 that reduce its transactivation activity in both yeast and mammalian cells weaken its binding to both yeast and human TFIIH. This suggests that binding of activation domains to TFIIH is an important aspect of transcriptional activation.
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Cited by
Transcriptional activation by recruitment
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Metadata
- Authors
- Xiao, H., Pearson, A., Coulombe, B., Truant, R., Zhang, S., Regier, J. L., Triezenberg, S. J., Reinberg, D., Flores, O., & Ingles, C. J.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1994-10
- Volume
- 14
- Issue
- 10
- Pages
- 7013-7024
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2154723040
- Cited by
- 361
- References
- 116
- FWCI
- 16.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Xiao, H., Pearson, A., Coulombe, B., Truant, R., Zhang, S., Regier, J. L., Triezenberg, S. J., Reinberg, D., Flores, O., & Ingles, C. J. (1994). Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.14.10.7013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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