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Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product
Abstract
Hepatocyte growth factor (HGF) is a plasminogen-like protein thought to be a humoral mediator of liver regeneration. A 145-kilodalton tyrosyl phosphoprotein observed in rapid response to HGF treatment of intact target cells was identified by immunoblot analysis as the β subunit of the c- met proto-oncogene product, a membrane-spanning tyrosine kinase. Covalent cross-linking of 125 I-labeled ligand to cellular proteins of appropriate size that were recognized by antibodies to c- met directly established the c- met product as the cell-surface receptor for HGF.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Cited by
Bussolino, F., Di Renzo, M. F., Ziche, M., Bocchietto, E., Olivero, M., Naldini, L., Gaudino, G., Tamagnone, L., Coffer, A., & Comoglio, P. M. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.629 · Cited by 1,337
Ponzetto, C., Bardelli, A., Zhen, Z., Maina, F., dalla Zonca, P., Giordano, S., Graziani, A., Panayotou, G., & Comoglio, P. M. (1994) · Cell · doi:10.1016/0092-8674(94)90318-2 · Cited by 991
Human skin pigmentation: Melanocytes modulate skin color in response to stress
Costin, G.-E., & Hearing, V. J. (2007) · The FASEB Journal · doi:10.1096/fj.06-6649rev · Cited by 976
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
Bafico, A., Liu, G., Yaniv, A., Gazit, A., & Aaronson, S. A. (2001) · Nature Cell Biology · doi:10.1038/35083081 · Cited by 772
Self-citationYano, S., Wang, W., Li, Q., Matsumoto, K., Sakurama, H., Nakamura, T., Ogino, H., Kakiuchi, S., Hanibuchi, M., Nishioka, Y., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1643 · Cited by 643
Metadata
- Authors
- Bottaro, D. P., Rubin, J. S., Faletto, D. L., Chan, A. M.-L., Kmiecik, T. E., Vande Woude, G. F., & Aaronson, S. A.
- Venue
- Science
- Published
- 1991-02-15
- Volume
- 251
- Issue
- 4995
- Pages
- 802-804
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054042846
- Cited by
- 2,236
- References
- 1
- FWCI
- 64.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product. https://app.cochat.ai/papers/10.1126/science.1846706
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- Bottaro, D. P., Rubin, J. S., Faletto, D. L., Chan, A. M.-L., Kmiecik, T. E., Vande Woude, G. F., & Aaronson, S. A. (1991). Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product. Science. https://doi.org/10.1126/science.1846706
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