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Brain Catechol Synthesis: Control by Brain Tyrosine Concentration
Abstract
Brain catechol synthesis was estimated by measuring the rate at which brain dopa levels rose following decarboxylase inhibition. Dopa accumulation was accelerated by tyrosine administration, and decreased by treatments that lowered brain tyrosine concentrations (for example, intraperitoneal tryptophan, leucine, or parachlorophenylalanine). A low dose of phenylalanine elevated brain tyrosine without accelerating dopa synthesis. Our findings raise the possibility that nutritional and endocrine factors might influence brain catecholamine synthesis by controlling the availability of tyrosine.
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Cited by
Tyrosine, Phenylalanine, and Catecholamine Synthesis and Function in the Brain2
Fernstrom, J. D., & Fernstrom, M. H. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.6.1539s · Cited by 755
Self-citationLarge neutral amino acids: dietary effects on brain neurochemistry and function
Fernstrom, J. D. (2013) · Amino Acids · doi:10.1007/s00726-012-1330-y · Cited by 317
Self-citationDopamine and depression: A review of recent evidence. I. Empirical studies
Willner, P. (1983) · Brain Research Reviews · doi:10.1016/0165-0173(83)90005-x · Cited by 273
INSULIN, GLUCAGON, AMINOACID IMBALANCE, AND HEPATIC ENCEPHALOPATHY
Soeters, P., & Fischer, J. (1976) · The Lancet · doi:10.1016/s0140-6736(76)90541-9 · Cited by 257
Effects of normal meals rich in carbohydrates or proteins on plasma tryptophan and tyrosine ratios
Wurtman, R. J., Wurtman, J. J., Regan, M. M., McDermott, J. M., Tsay, R. H., & Breu, J. J. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.128 · Cited by 247
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Metadata
- Authors
- Wurtman, R. J., Larin, F., Mostafapour, S., & Fernstrom, J. D.
- Venue
- Science
- Published
- 1974-07-12
- Volume
- 185
- Issue
- 4146
- Pages
- 183-184
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1977309516
- Cited by
- 367
- References
- 0
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wurtman, R. J., Larin, F., Mostafapour, S., & Fernstrom, J. D. (1974). Brain Catechol Synthesis: Control by Brain Tyrosine Concentration. Science. https://doi.org/10.1126/science.185.4146.183
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
