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Cited by 273Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionTryptophan and brain disorders

Dopamine and depression: A review of recent evidence. I. Empirical studies

Willner, Paul·1983·Brain Research Reviews
DOI 10.1016/0165-0173(83)90005-x
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Abstract

This paper reviews evidence from human, predominantly clinical, studies, relevant to the hypothesis that depression involves reduced levels of dopamine (DA) function. With the exception of Parkinson's disease, there is little evidence that treatments which decrease DA function are potent inducers of depression, but it is argued that such a relationship might not necessarily be expected. There is good evidence that the nigro-striatal DA system is underactive in retarded depressions, and some evidence that DA agonists are therapeutically effective in these cases. It remains unclear whether changes in DA function are primary or secondary.

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  • Phasic dopamine signals are important for stimulus-outcome association involving aversive stimuli, tonic changes of dopamine from a basal level to a low level trigger a negative affective state, and tonically low basal dopamine levels result in depression-like symptoms.

    “These observations may be explained by hypotheses that phasic dopamine signals are important for stimulus-outcome association involving aversive stimuli, that tonic changes of dopamine from a basal level to a low level trigger a negative affective state, and that tonically low basal dopamine levels result in depression-like symptoms (Willner, 1983).”

    From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Willner, 1983

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Authors
Willner, P.
Corresponding author
Willner, Paul
ORCID
Willner, Paul
Venue
Brain Research Reviews
Publisher
Elsevier BV
Published
1983-12
Volume
6
Issue
3
Pages
211-224
ISSN
0165-0173 (ISSN-L)
DOI
10.1016/0165-0173(83)90005-x
OpenAlex
W2007676211
Cited by
273
References
154
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 12 · 2013: 5 · 2012: 9
FWCI
0.71
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
dopamine, depression, dopaminergic activity, Parkinson's disease, dopamine agonists, nigrostriatal dopamine system, depression in Parkinson's disease
MeSH terms
Amphetamine, Brain, Bromocriptine, Depressive Disorder, Dihydroxyphenylalanine, Dopamine, Double-Blind Method, Homovanillic Acid, Humans, Norepinephrine, Parkinson Disease, Piribedil, Receptors, Dopamine, Research, Antipsychotic Agents

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