The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Endorphins: Profound Behavioral Effects in Rats Suggest New Etiological Factors in Mental Illness
Abstract
The endogenous morphinomimetic brain peptides Met 5 -enkephalin and α-, β-, and γ-endorphins have been evaluated in rats after intracerebrospinal fluid injection. β-Endorphin produces marked, prolonged muscular rigidity and immobility similar to a catatonic state, counteracted by the opiate antagonist naloxone; this effect occurs at molar doses 1/100 to 1/400 that at which the other peptides or morphine block the response to painful stimuli. All peptides evoked dose-related, naloxone-reversible, wet-dog shakes in rats that had not been exposed to drugs. β-Endorphin produced hypothermia, whereas γ-endorphin produced hyperthermia. Such potent and divergent responses to naturally occurring substances suggest that alterations in their homeostatic regulation could have etiological significance in mental illness.
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Citations
Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Cited by
β-Endorphin and Adrenocorticotropin Are Selected Concomitantly by the Pituitary Gland
Guillemin, R., Vargo, T., Rossier, J., Minick, S., Ling, N., Rivier, C., Vale, W., & Bloom, F. (1977) · Science · doi:10.1126/science.197601 · Cited by 1,419
Self-citationThe role of endorphins in stress: Evidence and speculations
Amir, S., Brown, Z. W., & Amit, Z. (1980) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(80)90027-5 · Cited by 351
Opiate antagonists stimulate affiliative behaviour in monkeys
Fabre-Nys, C., Meller, R. E., & Keverne, E. B. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90432-4 · Cited by 141
Surgical stress in humans is acompanied by an increase in plasma beta-endorphin immunoreactivity
Dubois, M., Pickar, D., Cohen, M. R., Roth, Y. F., Macnamara, T., & Bunney, W. E. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90230-7 · Cited by 141
Risch, S. C., Cohen, R. M., Janowsky, D. S., Kalin, N. H., & Murphy, D. L. (1980) · Science · doi:10.1126/science.7433977 · Cited by 140
Metadata
- Authors
- Bloom, F., Segal, D., Ling, N., & Guillemin, R.
- Venue
- Science
- Published
- 1976-11-05
- Volume
- 194
- Issue
- 4265
- Pages
- 630-632
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030288420
- Cited by
- 810
- References
- 1
- FWCI
- 33.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bloom, F., Segal, D., Ling, N., & Guillemin, R. (1976). Endorphins: Profound Behavioral Effects in Rats Suggest New Etiological Factors in Mental Illness. Science. https://doi.org/10.1126/science.185694
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
