The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Evidence for the Effects of a Superantigen in Rheumatoid Arthritis
Abstract
While studying the αβ T cell receptor repertoire in rheumatoid arthritis (RA) patients, we found that the frequency of V β 14 + T cells was significantly higher in the synovial fluid of affected joints than in the peripheral blood. In fact, V β 14 + T cells were virtually undetectable in the peripheral blood of a majority of these RA patients. β-chain sequences indicated that one or a few clones dominated the V β 14 + population in the synovial fluid of individual RA patients, whereas oligoclonality was less marked for other Vβ's and for V β 14 in other types of inflammatory arthritis. These results implicate V β 14-bearing T cells in the pathology of RA. They also suggest that the etiology of RA may involve initial activation of V β 14 + T cells by a V β 14-specific superantigen with subsequent recruitment of a few activated autoreactive V β 14 + T cell clones to the joints while the majority of other V β 14 + T cells disappear.
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Cites
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Self-citationTolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
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Self-citationT-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens
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Interleukin 6 plays a key role in the development of antigen-induced arthritis
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Metadata
- Authors
- Paliard, X., West, S. G., Lafferty, J. A., Clements, J. R., Kappler, J. W., Marrack, P., & Kotzin, B. L.
- Venue
- Science
- Published
- 1991-07-19
- Volume
- 253
- Issue
- 5017
- Pages
- 325-329
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982917969
- Cited by
- 630
- References
- 32
- FWCI
- 80.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Evidence for the Effects of a Superantigen in Rheumatoid Arthritis. https://app.cochat.ai/papers/10.1126/science.1857971
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- Paliard, X., West, S. G., Lafferty, J. A., Clements, J. R., Kappler, J. W., Marrack, P., & Kotzin, B. L. (1991). Evidence for the Effects of a Superantigen in Rheumatoid Arthritis. Science. https://doi.org/10.1126/science.1857971
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
