The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Design of Specific Inhibitors of Angiotensin-Converting Enzyme: New Class of Orally Active Antihypertensive Agents
Abstract
A hypothetical model of the active site of angiotensin-converting enzyme, based on known chemical and kinetic properties of the enzyme, has enabled us to design a new class of potent and specific inhibitors. These compounds, carboxyalkanoyl and mercaptoalkanoyl derivatives of proline, inhibit the contractile response of guinea pig ileal strip to angiotensin I and augment its response to bradykinin. When administered orally to rats, these agents inhibit the pressor effect of angiotensin I, augment the vasodepressor effect of bradykinin, and lower blood pressure in a model of renovascular hypertension.
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Cites
Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung
Cushman, D. W., & Cheung, H. S. (1971) · Biochemical Pharmacology · doi:10.1016/0006-2952(71)90292-9 · Cited by 2,625
Self-citationAngiotensin I converting enzyme.
Erdös, E. G. (1975) · Circulation Research · doi:10.1161/01.res.36.2.247 · Cited by 544
Ondetti, M. A., Williams, N. J., Sabo, E., Pluscec, J., Weaver, E. R., & Kocy, O. (1971) · Biochemistry · doi:10.1021/bi00798a004 · Cited by 521
Self-citationCarboxypeptidase A: A Protein and an Enzyme
Quiocho, F. A., & Lipscomb, W. N. (1971) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60278-8 · Cited by 400
Gavras, H., Brunner, H. R., Laragh, J. H., Sealey, J. E., Gavras, I., & Vukovich, R. A. (1974) · New England Journal of Medicine · doi:10.1056/nejm197410172911603 · Cited by 353
Cheung, H. S., & Cushman, D. W. (1973) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(73)90352-5 · Cited by 271
Self-citationBinding of the by-product analog benzylsuccinic acid by carboxypeptidase A
Byers, L. D., & Wolfenden, R. (1973) · Biochemistry · doi:10.1021/bi00735a008 · Cited by 195
Inhibition by SQ 20881 of vasopressor response to angiotensin I in conscious animals
Bianchi, A., Evans, D. B., Cobb, M., Peschka, M. T., Schaeffer, T. R., & Laffan, R. J. (1973) · European Journal of Pharmacology · doi:10.1016/0014-2999(73)90248-3 · Cited by 39
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Functional and bioactive properties of collagen and gelatin from alternative sources: A review
Gómez-Guillén, M. C., Giménez, B., López-Caballero, M. E., & Montero, M. P. (2011) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2011.02.007 · Cited by 2,052
Recent Advances in Zinc Enzymology
Lipscomb, W. N., & Sträter, N. (1996) · Chemical Reviews · doi:10.1021/cr950042j · Cited by 1,366
The influence of natural products upon drug discovery (Antiquity to late 1999)
Newman, D. J., Cragg, G. M., & Snader, K. M. (2000) · Natural Product Reports · doi:10.1039/a902202c · Cited by 1,293
Food-derived peptides with biological activity: from research to food applications.
Hartmann, R., & Meisel, H. (2007) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2007.01.013 · Cited by 1,102
Structure-Based Strategies for Drug Design and Discovery
Kuntz, I. D. (1992) · Science · doi:10.1126/science.257.5073.1078 · Cited by 989
Metadata
- Authors
- Ondetti, M. A., Rubin, B., & Cushman, D. W.
- Venue
- Science
- Published
- 1977-04-22
- Volume
- 196
- Issue
- 4288
- Pages
- 441-444
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000314850
- Cited by
- 1,856
- References
- 8
- FWCI
- 67.86
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
