Food-derived peptides with biological activity: from research to food applications.
Abstract
Many peptides that are released in vitro or in vivo from animal or plant proteins are bioactive and have regulatory functions in humans beyond normal and adequate nutrition. Different health effects have been attributed to food-derived peptides, including antimicrobial properties, blood pressure-lowering (ACE inhibitory) effects, cholesterol-lowering ability, antithrombotic and antioxidant activities, enhancement of mineral absorption and/or bioavailability, cyto- or immunomodulatory effects, and opioid activities. Numerous products are already on the market or under development by food companies that exploit the potential of food-derived bioactive peptides and which ascribe scientifically evidenced health claims to consumption of these functional foods.
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Antioxidant peptides can control both enzymatic and non-enzymatic peroxidation of fatty acids thus preventing membrane lipid peroxidation.
“Antioxidant peptides can control both enzymatic and non-enzymatic peroxidation of fatty acids thus preventing membrane lipid peroxidation (Hartmann and Meisel, 2007).”
From Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines (2016) · cites this paper as Hartmann and Meisel, 2007
Natural killer cell activity and antibody synthesis can be enhanced by food-derived bioactive peptides.
“Natural killer (NK) cell activity and antibody synthesis can also be enhanced by food–derived bioactive peptides (Hartmann and Meisel, 2007).”
From Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines (2016) · cites this paper as Hartmann and Meisel, 2007
Lactobacillus helveticus, Lactobacillus delbrueckii subsp. Bulgaricus SS1, Lactobacillus delbrueckii subsp. lactis, and Lactococcus lactis subsp. cremoris FT4 can modulate blood pressure by producing angiotensin 1-converting enzyme inhibitory peptides from milk proteins.
“Lactobacillus helveticus, Lactobacillus delbrueckii subsp. Bulgaricus SS1, Lactobacillus delbrueckii subsp. lactis, and Lactococcus lactis subsp. cremoris FT4 can modulate blood pressure by producing angiotensin 1-converting enzyme inhibitory peptides (ACE inhibitors) from milk proteins.”
From Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines (2016) · cites this paper as Hartmann and Meisel, 2007
The tripeptides Val-Pro-Pro and Ile-Pro-Pro, released from beta and K-casein by Lactobacillus helveticus, are immunomodulatory and hypotensive.
“the tripeptides Val-Pro-Pro and Ile-Pro-Pro, released from beta and K-casein by Lactobacillus helveticus are immunomodulatory and hypotensive (Hartmann and Meisel, 2007).”
From Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines (2016) · cites this paper as Hartmann and Meisel, 2007
ACE is a carboxypeptidase converting angiotensin I into angiotensin II, which has a strong vasoconstrictor action.
“ACE is a carboxypeptidase converting angiotensin I (a decapeptide) into angiotensin II (an octapeptide) having a strong vasoconstrictor action (Hartmann and Meisel, 2007).”
From Bioactive Molecules Released in Food by Lactic Acid Bacteria: Encrypted Peptides and Biogenic Amines (2016) · cites this paper as Hartmann and Meisel, 2007
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- Authors
- Hartmann, R., & Meisel, H.
- Corresponding author
- Meisel, Hans
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 18
- Issue
- 2
- Pages
- 163-169
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2075819111
- Cited by
- 1,102
- References
- 59
- Citations by year
- 2026: 18 · 2025: 38 · 2024: 39 · 2023: 42 · 2022: 50 · 2021: 57 · 2020: 90 · 2019: 80 · 2018: 84 · 2017: 62 · 2016: 63 · 2015: 85 · 2014: 76 · 2013: 78 · 2012: 78
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Health Sciences › Medicine › Oncology › Peptidase Inhibition and Analysis
- Keywords
- food-derived peptides, bioactive peptides, functional foods, health claims, antimicrobial peptides, angiotensin-converting enzyme inhibition, blood pressure reduction, cholesterol lowering, antithrombotic activity, antioxidant activity, mineral bioavailability, immunomodulation, opioid activity, proteolysis, food applications
- MeSH terms
- Biological Factors, Dietary Proteins, Food Analysis, Food Technology, Peptides, Therapeutic Human Experimentation, Nutritional Sciences
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