The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
The First Step in Vision: Femtosecond Isomerization of Rhodopsin
Abstract
The kinetics of the primary event in vision have been resolved with the use of femtosecond optical measurement techniques. The 11-cis retinal prosthetic group of rhodopsin is excited with a 35-femtosecond pump pulse at 500 nanometers, and the transient changes in absorption are measured between 450 and 580 nanometers with a 10-femtosecond probe pulse. Within 200 femtoseconds, an increased absorption is observed between 540 and 580 nanometers, indicating the formation of photoproduct on this time scale. These measurements demonstrate that the first step in vision, the 11-cis→11-trans torsional isomerization of the rhodopsin chromophore, is essentially complete in only 200 femtoseconds.
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Conical intersection dynamics of the primary photoisomerization event in vision
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Self-citation
Metadata
- Authors
- Schoenlein, R. W., Peteanu, L. A., Mathies, R. A., & Shank, C. V.
- Affiliations
- Lawrence Berkeley National Laboratory (US)
- University of California, Berkeley (US)
- Venue
- Science
- Published
- 1991-10-18
- Volume
- 254
- Issue
- 5030
- Pages
- 412-415
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2072516696
- Semantic Scholar
- 19e7973dd388e0a2bc35f1555e96aee3037a0645
- Cited by
- 892
- References
- 24
- Citations by year
- 2026: 31 · 2025: 29 · 2024: 20 · 2023: 31 · 2022: 22 · 2021: 33 · 2020: 25 · 2019: 20 · 2018: 32 · 2017: 32 · 2016: 28 · 2015: 38 · 2014: 25 · 2013: 32 · 2012: 30
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY 02051, T32EY007043)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Laser-Matter Interactions and Applications
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
- Keywords
- rhodopsin, retinal chromophore, photoproduct formation, femtosecond pump-probe spectroscopy, vision, photoisomerization kinetics, transient absorption spectroscopy
- MeSH terms
- Animals, Lasers, Light, Photochemistry, Rhodopsin, Spectrophotometry, Stereoisomerism, Time Factors, Vision, Ocular
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- The paper
- Schoenlein, R. W., Peteanu, L. A., Mathies, R. A., & Shank, C. V. (1991). The First Step in Vision: Femtosecond Isomerization of Rhodopsin. Science. https://doi.org/10.1126/science.1925597
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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