The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo
Abstract
Corticotropin-releasing hormone (CRH) functions as a regulator of the hypothalamic-pituitary-adrenal axis and coordinator of the stress response. CRH receptors exist in peripheral sites of the immune system, and CRH promotes several immune functions in vitro. The effect of systemic immunoneutralization of CRH was tested in an experimental model of chemically induced aseptic inflammation in rats. Intraperitoneal administration of rabbit antiserum to CRH caused suppression of both inflammatory exudate volume and cell concentration by approximately 50 to 60 percent. CRH was detected in the inflamed area but not in the systemic circulation. Immunoreactive CRH is therefore produced in peripheral inflammatory sites where, in contrast to its systemic indirect immunosuppressive effects, it acts as an autocrine or paracrine inflammatory cytokine.
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Cites
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083
Dunn, A. J., & Berridge, C. W. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90012-d · Cited by 1,352
Cited by
Stress and disorders of the stress system
Chrousos, G. P. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.106 · Cited by 3,215
Self-citationThe Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579
Self-citationElenkov, I. J., Wilder, R. L., Chrousos, G. P., & Vizi, E. S. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01470-4 · Cited by 2,252
Self-citationStress Hormones, Proinflammatory and Antiinflammatory Cytokines, and Autoimmunity
ELENKOV, I. J., & CHROUSOS, G. P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04229.x · Cited by 983
Self-citationMcEwen, B. S., Biron, C. A., Brunson, K. W., Bulloch, K., Chambers, W. H., Dhabhar, F. S., Goldfarb, R. H., Kitson, R. P., Miller, A. H., Spencer, R. L., et al. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00012-4 · Cited by 837
Metadata
- Authors
- Karalis, K., Sano, H., Redwine, J., Listwak, S., Wilder, R. L., & Chrousos, G. P.
- Venue
- Science
- Published
- 1991-10-18
- Volume
- 254
- Issue
- 5030
- Pages
- 421-423
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966449090
- Cited by
- 482
- References
- 2
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo. https://app.cochat.ai/papers/10.1126/science.1925600
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- Karalis, K., Sano, H., Redwine, J., Listwak, S., Wilder, R. L., & Chrousos, G. P. (1991). Autocrine or Paracrine Inflammatory Actions of Corticotropin-Releasing Hormone in Vivo. Science. https://doi.org/10.1126/science.1925600
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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